Clozapine-induced cardiomyopathy and myocarditis monitoring: A systematic review

The use of clozapine requires monitoring the absolute neutrophil count because of the risk of agranulocytosis, but other potentially fatal adverse events associated with clozapine (specifically, myocarditis and cardiomyopathy) do not have mandatory procedures. We performed a systematic review of English-language articles to synthesize an evidence-based approach for myocarditis and cardiomyopathy monitoring. Articles published from January 1988 through February 2017 were identified through a search of Ovid MEDLINE, Ovid Embase, Ovid Cochrane Database of Systematic Reviews, Web of Science, Scopus, and Google Scholar.

Source: Schizophrenia Research - March 13, 2018 Category: Psychiatry Authors: Kristen N. Knoph, Robert J. Morgan, Brian A. Palmer, Kathryn M. Schak, Amanda C. Owen, Megan R. Leloux, Mayur Patel, Jonathan G. Leung Source Type: research