Disrupted network cross talk, hippocampal dysfunction and hallucinations in schizophrenia

This study integrates two resting-state functional magnetic resonance imaging (fMRI) analysis methods – amplitudes of low-frequency fluctuations (ALFF) and functional network connectivity (FNC) – to explore the hypotheses that (1) abnormal FNC between salience and sensory (visual/auditory) networks underlies hallucinations in schizophrenia, and (2) disrupted hippocampal oscillations (as measured by hippocampal ALFF) beget changes in FNC linked to hallucinations.

Source: Schizophrenia Research - March 20, 2018 Category: Psychiatry Authors: Stephanie M. Hare, Alicia S. Law, Judith M. Ford, Daniel H. Mathalon, Aral Ahmadi, Eswar Damaraju, Juan Bustillo, Aysenil Belger, Hyo Jong Lee, Bryon A. Mueller, Kelvin O. Lim, Gregory G. Brown, Adrian Preda, Theo G.M. van Erp, Steven G. Potkin, Vince D. Source Type: research