Pulmonary artery hypertension in childhood: The transforming growth factor- β superfamily-related genes

Pulmonary artery hypertension (PAH) is very rare in childhood, and it can be divided into heritable, idiopathic drug- and toxin-induced and other disease (connective tissue disease, human immunodeficiency virus infection, portal hypertension, congenital heart disease, or schistosomiasis)-associated types. PAH could not be interpreted solely by pathophysiological theories. The impact of the transforming growth factor- β superfamily-related genes on the development of PAH in children remains to be clarified.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Tags: Review Article Source Type: research

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ConclusionExperiments show that the prognostic effect of the recurrent attention model is significantly higher than that of other traditional machine learning models. Because the model increases the attention mechanism, the important features affecting the prognostic results are obtained, which enables doctors to prescribe drugs according to the symptoms, take timely precautions and help patients to treat in time.Graphical abstract
Source: IRBM - Category: Biomedical Engineering Source Type: research
AbstractIn recent years, with the increasing aging of society, the number of patients with chronic heart disease, hypertension and diabetes has increased dramatically. It has guiding significance for the prevention and treatment by long-term monitoring of the physiological signs of patients with chronic diseases, scoring statistical data, and predicting the development trend of users ’ health. The work used the data collected by WIT120 system to analyze the pre-processed thick data based on adaptive k-means clustering method under the MapReduce framework, and the GM (1,1) grey model was used to predict the future hea...
Source: Health Care Management Science - Category: Hospital Management Source Type: research
ConclusionAlthough the investigated co-morbidities are capable or inducing pathophysiological changes that are predisposing factors for tumor progression, none is an independent prognostic factor in patients with RCC.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 11 September 2019Source: JACC: Heart FailureAuthor(s): Karen Sliwa, Lucia Baris, Christoph Sinning, Elvin Zengin-Sahm, Lina Gumbiene, Israa F. Yaseen, Ghada Youssef, Mark Johnson, Hasan Al-Farhan, Malgorzata Lelonek, Roger Hall, Jolien Roos-HesselinkAbstractBackgroundGlobally, congenital heart disease (CHD) is an important cause of maternal morbidity and mortality in women reaching reproductive stage. There is lack of data from larger cohorts of women with uncorrected CHD.ObjectivesTo study maternal and fetal outcome of women with uncorrected CHD.MethodsAn analysis of 10-year data from th...
Source: JACC: Heart Failure - Category: Cardiology Source Type: research
With the fast growth of the elderly population the number of proximal femur fractures is rising. In addition, these patients are often treated for chronical cardiovascular illnesses(1,2) such as coronary heart disease, hypertension, cerebrovascular disease and atrial fibrillation with anticoagulant medications(3,4). The attending surgeon has to decide for each case whether to continue, modify, bridge or even counteract the anticoagulation therapy, if surgery is necessary. For most patients on platelets inhibitors like Aspirin (ASS), Clopidogrel or Ticagrelor (PAI) the indication is a secondary prevention therapy after myocardial infarction.
Source: Injury - Category: Orthopaedics Authors: Source Type: research
AbstractObjectivesThe aim of the study was to investigate the ability of the systemic inflammatory parameters to predict the discrimination of the phases of Peyronie's disease (PD).Materials and methodsDemographic, clinical, and laboratory data from 156 patients with PD were analyzed. A complete blood count (CBC) was obtained for every patient, and the neutrophil ‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), and monocyte‐to‐eosinophil ratio (MER) were calculated for every men. Subsequently, patients were divided into two groups based upon the phase of the disease.ResultsThe mean age was 51.9 &...
Source: Andrology - Category: Urology & Nephrology Authors: Tags: Original Article Source Type: research
Diabetes has grown to become one of the most important public health concerns of our time. A review by the Harvard T.H. Chan School of Public Health has shown that the number of affected people has quadrupled in the last three decades. Type 2 diabetes (T2D), a type of diabetes traditionally occurring in adults and associated with obesity and a sedentary lifestyle, is now the ninth leading cause of death worldwide. It therefore comes as no surprise that this rapidly emerging epidemic is giving rise to a profusion of diabetes-related complications. What are the usual diabetes-related complications? As diabetes is a systemic ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Diabetes Health Source Type: blogs
Hypertension, affecting 31.1% of the adult population worldwide, contributes considerably to the global burden of health problems.1 It increases the risk of heart disease, stroke, and kidney failure.2 In China, the prevalence of hypertension is high and varied significantly by sex and age. It is estimated that the prevalence of hypertension in China was 35.7% in adults aged 45 –59 and 58.9% in those aged over 60 in 2012 and women reported a higher rate of hypertension than men (57.6% vs. 42.4%).3,4 Hypertension accounts for approximately 9.4 million deaths every year in the world.
Source: Heart and Lung - Category: Intensive Care Authors: Source Type: research
AbstractThe renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in the regulation of blood pressure and volume homeostasis, promoting critical structural changes in every component of the cardiovascular system, including the heart and blood vessels. Consequently, the RAAS is a crucial therapeutic target for several chronic diseases of the cardiovascular system, spanning from arterial hypertension (AH) to heart failure (HF). AH represents a leading risk factor for the development of symptomatic HF, particularly with left ventricle (LV) preserved ejection fraction (HFpEF). LV diastolic dysfunction and cardiac re...
Source: Heart Failure Reviews - Category: Cardiology Source Type: research
Authors: Jany B, Bals R, Dreher M, Held M, Jany L, Rembert Koczulla A, Pfeifer M, Randerath W, Watz H, Wilkens H, Steinkamp G Abstract When caring for patients with respiratory diseases, always think of the heart! This is especially important for COPD patients, but also for a variety of other disorders of the respiratory system. At the workshop "Luftschlösser", held once more at Wiesbaden, Germany in February 2019 the many and important interactions of the lungs and the heart as well as the therapeutic implications were discussed. Based on pathophysiology, the psycho-social consequences of dyspnea, t...
Source: Pneumologie - Category: Respiratory Medicine Tags: Pneumologie Source Type: research
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