Sirenomelia with VACTERL association-a rare anomaly

Sirenomelia is a rare congenital disorder with complete or partial fusion of lower limbs. The incidence of Sirenomelia is reported to vary from 0.01 –0.16/10,000 live births with male to female ratio of 3:1.1 Risk factors include maternal gestational diabetes mellitus, tobacco use, and retinoic acid and heavy metal exposure. Sirenomelia is usually incompatible with life due to associated visceral anomalies. Here, we report a rare case of Siren omelia with multiple associated anomalies in the VACTERL spectrum which suggest a link in the pathogenesis between the two conditions.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Tags: Short Communication Source Type: research

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Source: BMJ Comments - Category: General Medicine Source Type: forums
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Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
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