Extraction of unadjusted estimates of prognostic association for meta-analysis: simulation methods as good alternatives to trend and direct method estimation

Systematic reviews and meta-analysis are the standard methods to assess the association between prognostic markers and major events/conditions. However, the summary measures reported are not always explicitly presented and therefore different indirect methods of extracting estimates have been proposed. The aim of this study is to present two new alternative methods for obtaining summary statistics to be included in a meta-analysis of prognostic studies based on simulating individual patient data and to compare them with the already known generalized least squares for trend (glst) estimation method and direct method.
Source: Journal of Clinical Epidemiology - Category: Epidemiology Authors: Tags: Original Article Source Type: research