Hypericum perforatum to improve post-operative Pain Outcome after monosegmental Spinal microdiscectomy (HYPOS): a study protocol for a randomised, double-blind, placebo-controlled trial

This study is aimed to investigate whether homeopathicH. perforatum in a potentisation of C200 leads to the reduction of post-operative pain and a decrease of pain medication compared to placebo.Methods/designThis is a monocentric, double-blind, randomised placebo-controlled trial conducted at the Department of Neurosurgery at the Community Hospital Herdecke, Germany. One hundred study participants are being recruited from inpatients undergoing elective, monosegmental, lumbar microdiscectomy surgery. Patients are randomly allocated to receive homeopathic treatment or placebo in addition to usual pain management after surgery. The primary clinical outcome is pain reduction after 3 days of inpatient care as measured by pain reduction of subjective pain on a 100-mm Visual Analogue Scale (VAS) at the third post-operative day. Statistical analysis will be carried out by means of a covariance model with adjustment for baseline values and patient expectation for all randomised patients.DiscussionThis study is the first trial of classical homeopathy that will evaluate the efficacy of homeopathicH. perforatum after monosegmental spinal microdiscectomy. We intend to clarify the potential of homoeopathicH. perforatum to reduce surgery-associated pain.Trial registrationGerman Clinical Trials Register, ID:DRKS00007913. Registered on 17 October 2014.EudraCT – Nr: 2013–001383-31.Data sets from the German Clinical Trials Register (DRKS, Deutsches Register Klinischer Studien) are ...
Source: Trials - Category: Research Source Type: clinical trials

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Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Physiatry Reviews for Evidence in Practice Source Type: research
ConclusionSclerosis can occur in endplates with any type of MCs. However, the clinical and animal study suggests that sclerosis is greatest in endplates showing type III MCs.The translational potential of this articleThe study showed that sclerosis can occur in endplates with MCs type I, II and III. In patients with endplate sclerosis on plain radiographs or CT scans, the endplate can still represent an inflammatory process associated with chronic lower back pain.
Source: Journal of Orthopaedic Translation - Category: Orthopaedics Source Type: research
Publication date: Available online 17 August 2018Source: Pharmacological ResearchAuthor(s): Sajad Fakhri, Fatemeh Abbaszadeh, Leila Dargahi, Masoumeh JorjaniAbstractAstaxanthin (AST) is a potent lipid-soluble keto-carotenoid with auspicious effects on human health. It protects organisms against a wide range of diseases with excellent safety and tolerability. Various imperative biological activities in vitro and in vivo models have been suggested for AST.This review article is focused on the therapeutic potentials, biological activities and benefical health effects of AST. The pharmacological mechanisms of action of AST in ...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
American physicians dole out lots of unnecessary medical care to their patients. They prescribe things like antibiotics for people with viral infections, order expensive CT scans for patients with transitory back pain, and obtain screening EKGs for people with no signs or symptoms of heart disease. Some critics even accuse physicians of ordering such services to bolster their revenue. So what happens when uninsured patients make it to the doctor’s office with coughs, low back pain, or other problems? Do physicians stop ordering all these unnecessary tests and services, out of recognition that most of these patients w...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Policy Medicare Public Health & Source Type: blogs
Conditions:   Chronic Low Back Pain;   Postural Low Back Pain Interventions:   Other: Control. no therapeutic program;   Other: Experimental. Therapeutic program Sponsor:   University of Extremadura Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
No abstract available
Source: The Back Letter - Category: Orthopaedics Tags: Articles Source Type: research
No abstract available
Source: The Back Letter - Category: Orthopaedics Tags: Articles Source Type: research
Publication date: Available online 16 August 2018Source: NeuronAuthor(s): Yan Zhang, Shenbin Liu, Yu-Qiu Zhang, Martyn Goulding, Yan-Qing Wang, Qiufu MaSummaryThe gate control theory proposes that Aβ mechanoreceptor inputs to spinal pain transmission T neurons are gated via feedforward inhibition, but it remains unclear how monosynaptic excitation is gated by disynaptic inhibitory inputs that arrive later. Here we report that Aβ-evoked, non-NMDAR-dependent EPSPs in T neurons are subthreshold, allowing time for inhibitory inputs to prevent action potential firing that requires slow-onset NMDAR activation. Pot...
Source: Neuron - Category: Neuroscience Source Type: research
This study aimed to evaluated the anti-inflammatory activity of KM1608, which is composed of three natural herbs in a mouse model of dextran sodium sulfate (DSS)-induced ulcerative colitis. The anti-inflammatory activity and underlying mechanism were assessed in vitro using LPS-treated RAW264.7 cells. The in vivo effect of KM1608 on DSS-induced colitis was examined after oral administration in mice. KM1608 significantly inhibited the inflammatory mediators such as nitric oxide, interleukin (IL)-6, monocyte chemotactic protein 1 (MCP-1) and tumor necrosis factor (TNF)-α in LPS-treated RAW264.7 cells. The inhibitor...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
The skeleton is a common site for cancer metastases. Bone metastases are a major cause of morbidity and mortality and associated with pain, pathologic fractures, spinal cord compression, and decreased survival. Various radionuclides have been used for pain therapy. Recently, an α-emitter has been shown to improve overall survival of patients with bone metastases from castration-resistant prostate cancer and was approved as a therapeutic agent. The aim of this article is to provide an overview regarding state of the art radionuclide therapy options for bone metastases, wit h focus on the role of PET imaging in therapy planning.
Source: PET Clinics - Category: Radiology Authors: Source Type: research
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