Hypericum perforatum to improve post-operative Pain Outcome after monosegmental Spinal microdiscectomy (HYPOS): a study protocol for a randomised, double-blind, placebo-controlled trial

This study is aimed to investigate whether homeopathicH. perforatum in a potentisation of C200 leads to the reduction of post-operative pain and a decrease of pain medication compared to placebo.Methods/designThis is a monocentric, double-blind, randomised placebo-controlled trial conducted at the Department of Neurosurgery at the Community Hospital Herdecke, Germany. One hundred study participants are being recruited from inpatients undergoing elective, monosegmental, lumbar microdiscectomy surgery. Patients are randomly allocated to receive homeopathic treatment or placebo in addition to usual pain management after surgery. The primary clinical outcome is pain reduction after 3 days of inpatient care as measured by pain reduction of subjective pain on a 100-mm Visual Analogue Scale (VAS) at the third post-operative day. Statistical analysis will be carried out by means of a covariance model with adjustment for baseline values and patient expectation for all randomised patients.DiscussionThis study is the first trial of classical homeopathy that will evaluate the efficacy of homeopathicH. perforatum after monosegmental spinal microdiscectomy. We intend to clarify the potential of homoeopathicH. perforatum to reduce surgery-associated pain.Trial registrationGerman Clinical Trials Register, ID:DRKS00007913. Registered on 17 October 2014.EudraCT – Nr: 2013–001383-31.Data sets from the German Clinical Trials Register (DRKS, Deutsches Register Klinischer Studien) are ...
Source: Trials - Category: Research Source Type: clinical trials

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Publication date: Available online 20 June 2018 Source:Brain, Behavior, and Immunity Author(s): Xin Zhang, Jane E. Hartung, Andrey V. Bortsov, Seungtae Kim, Sandra C. O'Buckley, Julia Kozlowski, Andrea G. Nackley Functional pain syndromes, such as fibromyalgia and temporomandibular disorder, are associated with enhanced catecholamine tone and decreased levels of catechol-O-methyltransferase (COMT; an enzyme that metabolizes catecholamines). Consistent with clinical syndromes, our lab has shown that sustained 14-day delivery of the COMT inhibitor OR486 in rodents results in pain at multiple body sites and pain-related voli...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Medtronic seems to be on a roll when it comes to innovation. The Dublin-based company has received the greenlight from FDA for an expanded indication of the Kyphon HV-R Bone Cement. Under the new indication, Medtronic can market Kyphon for the fixation of pathological fractures of the sacral vertebral body using sacral vertebroplasty or sacroplasty. Sacral insufficiency fractures (SIFs) are a common cause of debilitating back pain. SIFs mimic the symptoms of lumbar spine pathology. Studies show more than two-thirds of patients diagnosed with SIFs aren't able to associate their pain with a traumatic event. As a result, phys...
Source: MDDI - Category: Medical Devices Authors: Tags: Orthopedics Source Type: news
(Natural News) There have been many claims of effective nutritional treatments for pain caused by dysmenorrhea, but few have actual studies to back them up. A randomized double-blinded trial conducted in India found that thiamine or vitamin B1 could provide some much-needed comfort from menstrual cramps. The study involved over 550 women, 277 of whom...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Conditions:   Low Back Pain;   Facet Joint Pain;   Facet Syndrome of Lumbar Spine;   Chronic Low Back Pain Interventions:   Procedure: Ultrasound-Guided Thermocoagulation of Lumbar facet joints;   Procedure: Fluoroscopy-Guided Thermocoagulation of Lumbar facet joints Sponsor:   Erasme University Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Anxiety can stymie our lives in so many ways. Whether it’s a debilitating panic attack, constant worry or an all pervading fear, anxiety is often an unwanted companion that seemingly only wants the worst for us. However with the right help, guidance and support, there are a variety of techniques that can help. Of course it’s important to note that we’re all different, and what works for one person may not be as effective on another, but from personal experience, my own road to recovery led me, thankfully, to yoga therapy. After years of struggling with depression and anxiety, I moved to to South East Asia...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Alternative and Nutritional Supplements Anxiety and Panic Brain and Behavior Exercise & Fitness General Habits Happiness Health-related Mental Health and Wellness Mindfulness Personal Compassion Integrative Medicine Mind Body Wel Source Type: blogs
Conditions:   Low Back Pain;   Facet Joint Pain;   Facet Syndrome of Lumbar Spine;   Chronic Low Back Pain Interventions:   Procedure: Ultrasound-Guided Thermocoagulation of Lumbar facet joints;   Procedure: Fluoroscopy-Guided Thermocoagulation of Lumbar facet joints Sponsor:   Erasme University Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We report the first case of iatrogenic spinal cord injury during a CT-guided cervical TFESI. A 67-year-old woman, upon receiving TFESI on Lt. C7, experienced an electrical shock-like sensation throughout the body. The patient complained of weakness in the left upper and lower extremities (manual muscle testing grade: 2–4) and neuropathic pain (numeric rating scale: 9) in the left upper and lower extremities. Cervical magnetic resonance imaging (MRI) performed 9 days after TFESI showed a high T2 signal at the left side of the spinal cord from levels C5 to C7, and an electrophysiological study performed 14 days after T...
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Case Report Source Type: research
WEDNESDAY, June 20, 2018 -- In back-related leg pain and sciatica patients, belief in a long recovery and the number of other symptoms attributed to the pain are independently negatively associated with improvement, according to a study published in...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
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Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Conclusions Spinal protein kinase M ζ regulation of GluA1-containing AMPA receptor trafficking and spine morphologyvia Kalirin-7 overexpression is a fundamental pathogenesis of remifentanil-induced hyperalgesia in rats.
Source: Anesthesiology - Category: Anesthesiology Source Type: research
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