Long-acting insulin analogs and cancer

Hyperinsulinemia is a recognized risk factor for cancer and plays a major role for the  increased cancer incidence in diabetic patients. Whether insulin analogs, and particularly long-acting analogs, worsen the pro-cancer effect of excess insulin is still controversial.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Tags: Review Source Type: research

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In this study, we verified that ferroptosis occurred in animal models of arsenic-induced pancreatic dysfunction through assessing proferroptotic markers and morphological changes in mitochondria. In vitro, arsenic caused execution of ferroptosis in a dose-dependent manner, which could be significantly reduced by ferrostatin-1. Additionally, arsenic damaged mitochondria manifested as diminishing of mitochondrial membrane potential, reduced cytochrome c level and production of mitochondrial reactive oxygen species (MtROS) in MIN6 cells. Using the Mito-TEMPO, we found the autophagy level and subsequent ferroptotic cell death ...
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
Publication date: January 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 129, Issue 1Author(s): Dalal Alhajji, Yoon Ah Danskin, Bridget O'hara, Karl Armand Solano, Jessica Flynn, Elyn Riedel, Sae Hee Kim Yom, Cherry EstiloObjectivesOsteoradionecrosis (ORN) is a complication of head and neck radiation therapy (RT) and is associated with significant morbidity. The incidence of ORN is variable, and it has been speculated to be lower with advanced RT techniques. Risk factors that have been associated with the development of ORN mainly include trauma and a radiation dose to the head and neck ...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
This study shows that CA are released from periventricular and subpial regions to the cerebrospinal fluid and are present in the cervical lymph nodes, into which cerebrospinal fluid drains through the meningeal lymphatic system. We also show that CA can be phagocytosed by macrophages. We conclude that CA can act as containers that remove waste products from the brain and may be involved in a mechanism that cleans the brain. Moreover, we postulate that CA may contribute in some autoimmune brain diseases, exporting brain substances that interact with the immune system, and hypothesize that CA may contain brain markers that m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Authors: Abbott KL, Flannery PC, Gill KS, Boothe DM, Dhanasekaran M, Mani S, Pondugula SR Abstract Adverse pharmacokinetic interactions between illicit substances and clinical drugs are of a significant health concern. Illicit substances are taken by healthy individuals as well as by patients with medical conditions such as mental illnesses, acquired immunodeficiency syndrome, diabetes mellitus and cancer. Many individuals that use illicit substances simultaneously take clinical drugs meant for targeted treatment. This concomitant usage can lead to life-threatening pharmacokinetic interactions between illicit subst...
Source: Drug Metabolism Reviews - Category: Drugs & Pharmacology Tags: Drug Metab Rev Source Type: research
This article shares 5 ways to help stop these uncomfortable morning feelings and also explains when it’s time to see a therapist. Ginny Fuchs Hopes to Emerge From OCD, Tearful Olympic Experience: Virginia “Ginny” Fuchs, an American flyweight boxer and Olympic hopeful, has struggled with obsessive compulsive disorder (OCD) since 5th grade. She expresses that boxing gives her hope against the disorder. “You’ve got to keep training to keep winning in boxing. So I’ve got to keep training my OCD thoughts and how to handle and manage it,” she says. “…I have this environment ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anxiety and Panic Disorders General Mental Health and Wellness Mindfulness OCD Psychology Around the Net Relationships Substance Abuse Trauma Violence and Aggression Addiction aging mothers caregiving Health Insurance Olympic Source Type: blogs
BEST supplements for weight loss: Losing weight is extremely important as weighing too much is not good for one ’s health. Being overweight increases a person's risk of health conditions such as heart problems, high blood pressure, type 2 diabetes and certain types of cancer. Luckily, there is a supplement one can take to help make the journey of weight loss a bit easier.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 12 December 2019Source: Chemico-Biological InteractionsAuthor(s): Kohtaro Kikuchi, Hidekazu TsukamotoAbstractStearoyl-CoA desaturase (SCD) generates monounsaturated fatty acids (MUFAs) which contribute to cell growth, survival, differentiation, metabolic regulation and signal transduction. Overexpression of SCD is evident and implicated in metabolic diseases such as diabetes and non-alcoholic fatty liver disease. SCD also stimulates canonical Wnt pathway and YAP activation in support of stemness and tumorigenesis. SCD facilitates metabolic reprogramming in cancer which is mediated, at lea...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
ConclusionsThe results of this population-based study indicate that use of long-acting insulin analogs is not associated with an overall increased risk of colorectal cancer.
Source: Drug Safety - Category: Drugs & Pharmacology Source Type: research
It's Official, Hahn Will Lead FDA The U.S. Senate voted 72-18 to confirm Stephen Hahn, MD, as the new FDA Commissioner. The news has been well received by industry advocacy groups like AdvaMed and professional societies like the American Heart Association. Hahn is a radiation oncologist who specializes in treating lung cancer and sarcoma.   3M Calls It Quits on Drug Delivery The company plans to sell most of its drug-delivery business to an affiliate of Altaris Capital Partners for $650 million plus a 17% noncontrolling interest...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Source Type: news
Publication date: Available online 12 December 2019Source: Journal of Molecular Graphics and ModellingAuthor(s): Sabahuddin Ahmad, Sudha Bhagwati, Sushil Kumar, Dibyendu Banerjee, Mohammad Imran SiddiqiAbstractCathepsin S (CatS) is one of the cysteinyl cathepsins widely studied for its clinical significance and found to be a promising therapeutic target for several diseases; to name a few is arthritis, allergic inflammation, cancer, diabetes, obesity, and cystic fibrosis. Elevated CatS level is a contributing factor for related disorders, and therefore among different strategies to regulate the activity of CatS, one is to ...
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
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