Cardiac effects of fish oil in a rat model of streptozotocin-induced diabetes

This study aims to evaluate effects of FO in a rat model of streptozotocin (STZ) induced diabetes.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research

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In this study, we verified that ferroptosis occurred in animal models of arsenic-induced pancreatic dysfunction through assessing proferroptotic markers and morphological changes in mitochondria. In vitro, arsenic caused execution of ferroptosis in a dose-dependent manner, which could be significantly reduced by ferrostatin-1. Additionally, arsenic damaged mitochondria manifested as diminishing of mitochondrial membrane potential, reduced cytochrome c level and production of mitochondrial reactive oxygen species (MtROS) in MIN6 cells. Using the Mito-TEMPO, we found the autophagy level and subsequent ferroptotic cell death ...
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
CONCLUSIONS: The use of metformin was associated with a reduced risk of HCC, and it may be a relevant factor for preventing HCC in diabetic patients. PMID: 31836424 [PubMed - as supplied by publisher]
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
This study aimed to review the outcomes of percutaneous treatment with a mother-child technique in the treatment of symptomatic central venous stenosis (CVS) and central venous occlusion (CVO) in patients on hemodialysis.MethodsData were collected retrospectively and included all consecutive patients with CVS or CVO who were treated with percutaneous angioplasty and stenting. The occlusive lesions were crossed using the mother-child technique with an angiographic catheter-in-guiding catheter system.ResultsA total of 36 patients with symptomatic CVS and 45 patients with total CVO were included. The average age and gender co...
Source: Journal of Vascular Surgery: Venous and Lymphatic Disorders - Category: Surgery Source Type: research
Biochemist and ophthalmologist whose research concentrated on the formation of cataractsRuth van Heyningen, who has died aged 101, was a pioneering explorer of ophthalmic biochemistry, a field to which she made major contributions after she joined the Nuffield Laboratory of Ophthalmology, at Oxford University, in 1951.Her research, much of which was carried out in collaboration with the laboratory ’s then director,Antoinette (Tony) Pirie, was focused on the lens, in particular the biochemical pathways involved in the formation of cataracts. Tony and Ruth wrote a key book together, Biochemistry of the Eye (1956), whic...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Biochemistry and molecular biology Cataracts People in science University of Oxford Diabetes Wales Source Type: news
Source: BMJ Comments - Category: General Medicine Source Type: forums
Publication date: January 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 129, Issue 1Author(s): Dalal Alhajji, Yoon Ah Danskin, Bridget O'hara, Karl Armand Solano, Jessica Flynn, Elyn Riedel, Sae Hee Kim Yom, Cherry EstiloObjectivesOsteoradionecrosis (ORN) is a complication of head and neck radiation therapy (RT) and is associated with significant morbidity. The incidence of ORN is variable, and it has been speculated to be lower with advanced RT techniques. Risk factors that have been associated with the development of ORN mainly include trauma and a radiation dose to the head and neck ...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Publication date: January 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 129, Issue 1Author(s): RAYZA RECHETNICOU, MARIA FERNANDA BARTHOLO SILVA, NATÁLIA SILVA ANDRADE, KAREM LOPEZ ORTEGA, MARINA HELENA CURY GALLOTTINIObjectiveThe life expectancy of people positive for human immunodeficiency virus (HIV) has increased since the advent of combined antiretroviral therapy (CART). There was a decrease in opportunistic infections in this population, but on the other hand, there were side effects to medications and medical conditions related to longevity. The main of this prospective stu...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
ConclusionsEosinophilic ulcer is likely a reactive painful lesion that mainly affects the tongue of adults, which may clinically mimic oral SCC.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
ConclusionsChanges in oral microbiota are related to changes in the salivary pH associated with metabolic control of type 2 diabetes.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Mucormycosis is an aggressive and highly lethal pathology caused by an opportunistic fungus of the Mucorales order. Mucormycosis occurs particularly in patients with an impaired immune response. A 57-year-old woman with uncontrolled diabetes presented with palatal necrosis and hardening of the subcutaneous tissue at the level of the maxillary sinus associated with otalgia and myalgia. The patient was receiving antibiotic and antifungal therapy. The computed tomography (CT) exam showed gas bubbles in the left pterygopalatine fossa, originating from the extensive necrotic lesion of the palate and communication between these areas.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
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