[Articles] The effect of APOE and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study

Common variants with small individual effects jointly modify the risk and age at onset of Alzheimer's disease and dementia, particularly in APOE ε4 carriers. These findings highlight the potential of common variants in determining Alzheimer's disease risk.

Source: Lancet Neurology - March 16, 2018 Category: Neurology Authors: Sven J van der Lee, Frank J Wolters, M Kamran Ikram, Albert Hofman, M Arfan Ikram, Najaf Amin, Cornelia M van Duijn Tags: Articles Source Type: research