[Comment] Prediction to prevention in Alzheimer's disease and dementia

Risks of dementia and Alzheimer's disease reflect the combined effects of age, genetic variants, and social and behavioural determinants.1 In The Lancet Neurology, Sven van der Lee and colleagues2 use data from the Rotterdam Study to address the important task of predicting whether an individual is likely to develop Alzheimer's disease or dementia in his or her lifetime. In this cohort, a genetic risk score (GRS) of 23 genetic variants modified the risk of late-onset Alzheimer's disease or dementia above and beyond the effect of the gene for apolipoprotein E (APOE).

Source: Lancet Neurology - April 25, 2018 Category: Neurology Authors: Carole Dufouil, M Maria Glymour Tags: Comment Source Type: research