Direct oral anticoagulants do not inhibit growth and metastasis of human triple negative breast cancer in immunodeficient mice

Introduction: It has been well-established that cancer results in a hypercoagulable state and an increased risk for venous thromboembolism (VTE). More recently, it has been suggested that coagulation may also affect cancer progression and metastasis. Cancer patients with VTE are currently treated with the anticoagulant low molecular weight heparins (LMWHs). Preclinical studies have shown that LMWHs can inhibit metastasis formation in several types of cancer, but beneficial effects of LMWHs on survival have not been consistently found in clinical trials.

Source: Thrombosis Research - April 1, 2018 Category: Hematology Authors: J.T. Buijs, E.H. Laghman, R.F.P. van den Akker, C. Tieken, E. Vletter, K. van der Molen, J. Crooijmans, C. Kroone, G. van der Pluijm, S.E. le D évédec, H.H. Versteeg Tags: PO-50 Source Type: research