Deficiency in the DNA glycosylases UNG1 and OGG1 does not potentiate c-Myc-induced B-cell lymphomagenesis

Lymphomas are a group of cancers that occur in lymphoid tissue during lymphocyte development. The majority of lymphomas (95%) are of B-cell origin [1], and despite the extensive research focusing on understanding the molecular events leading to this disease, the full mechanistic details remain elusive. It is now accepted that the natural processes guiding normal B-cell activation and differentiation are at the root of B-cell transformation. B cells are highly susceptible to chromosomal translocations, mainly due to the fact that the process of antibody diversification involves naturally induced DNA breaks and mutations [2].

Source: Experimental Hematology - February 26, 2018 Category: Hematology Authors: Blerta Green, Alberto Martin, Antoaneta Belcheva Source Type: research