Megakaryocyte ontogeny: Clinical and molecular significance

Megakaryocytes (Mks) are specialized mammalian marrow cells responsible for platelet production. They arise from bipotent megakaryocyte-erythroid progenitors [1]. Their differentiation includes a unique program of endomitosis that drives nuclear polyploidization and cellular enlargement. This process is accompanied by lineage consolidation involving downregulation of erythroid genes and upregulation of Mk surface markers, as well as development of cytoplasmic granules, multivesicular bodies, and demarcation membranes.

Source: Experimental Hematology - February 28, 2018 Category: Hematology Authors: Kamaleldin E. Elagib, Ashton T. Brock, Adam N. Goldfarb Tags: Review Source Type: research