Analysis of relapse after transplantation in acute leukemia: A comparative on second allogeneic hematopoietic cell transplantation and donor lymphocyte infusions

Relapse of acute leukemia (AL) after allogeneic hematopoietic cell transplantation (Allo-HCT) entails a dismal prognosis and its approach remains challenging. The relapse rate of acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) after transplantation vary between 30% and 50%, depending on a wide range of factors such as the transplantation platform [1], disease risk [2], and the intensity of T-cell depletion (TCD) [3], among others. Posttransplantation relapse is associated with poor survival rates [4 –6].

Source: Experimental Hematology - March 8, 2018 Category: Hematology Authors: Guillermo Ort í, Jaime Sanz, Irene García-Cadenas, Isabel Sánchez-Ortega, Laura Alonso, Maria José Jiménez, Luisa Sisinni, Carmen Azqueta, Olga Salamero, Isabel Badell, Christelle Ferra, Cristina Diaz de Heredia, Rocio Parody, Miguel Angel Sanz, Jorg Source Type: research