Senescent human hematopoietic progenitors show elevated expression of transposable elements and inflammatory genes

Cellular senescence, a state of permanent cell cycle arrest, can be induced by a variety of stressors [1]. Senescence plays a role in tumor suppression and escape from senescence has been identified as a set of cellular processes that can lead to the development of cancer [2]. Approximately 50% of the genome is composed of transposable elements (TEs) [3,4] and we recently characterized the expression of TEs during the development of acute myeloid leukemia (AML), a malignancy considered to arise from hematopoietic stem/progenitor cells (HSPCs) [5].
Source: Experimental Hematology - Category: Hematology Authors: Tags: Brief Communication Source Type: research