Synergistic Action of Dual IGF1/R and MEK Inhibition Sensitizes Childhood Acute Lymphoblastic Leukaemia (ALL) Cells to Cytotoxic Agents and Involves Down-Regulation of STAT6 and PDAP1

Although cure rates for childhood ALL have increased dramatically over recent years through the integration of risk-stratification into treatment protocols [1-3], failure of remission-inducing therapy is associated with only a 30% ten-year survival rate [4] and relapsed ALL remains the commonest cause of cancer-related death in children [5-7]. There is a need for new therapeutic approaches with minimal toxicities for higher-risk leukaemias.

Source: Experimental Hematology - April 12, 2018 Category: Hematology Authors: Victoria J Weston, Wenbin Wei, Tatjana Stankovic, Pamela Kearns Source Type: research