Metabolic Syndrome and Cardiovascular Risk Factors after Hematopoietic Cell Transplantation in Severe Mucopolysaccharidosis Type I (Hurler Syndrome)
Annually, more than 20,000 hematopoietic cell transplantation (HCTs) are performed in the United States for malignant as well as nonmalignant (often rare) diseases of childhood [1]. Long-term survivors of HCT are at an increased risk of death from long-term sequelae as well as increased risk of cardiovascular disease [2]. Current international guidelines recommend frequent monitoring of long-term survivors for the development of metabolic syndrome (MetS) [3,4] —a constellation of central obesity, high blood pressure, low high-density lipoprotein (HDL) cholesterol, elevated fasting blood glucose, and triglycerides—that is associated with increased cardiovascular risk [5-9].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Elizabeth Braunlin, Julia Steinberger, Todd DeFor, Paul Orchard, Aaron S. Kelly Source Type: research
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