Vedolizumab Treatment May Reduce Steroid Burden and Improve Histology in Patients With Eosinophilic Gastroenteritis

Eosinophilic gastritis (EG) and eosinophilic gastroenteritis (EGE) are rare diseases characterized by marked eosinophilic infiltration of the gastrointestinal (GI) tract, and symptoms that typically reflect the location(s) of GI involvement.1,2 Knowledge of these conditions is limited, and treatments, which largely are based on case series, most frequently involve corticosteroids. Because long-term steroid treatment is fraught with complications, novel treatment options are needed.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Research Correspondence Source Type: research

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Publication date: Available online 11 December 2019Source: Best Practice &Research Clinical Endocrinology &MetabolismAuthor(s): Edith Lahner, Laura Conti, Francesco Cicone, Silvia Capriello, Maria Cazzato, Marco Centanni, Bruno Annibale, Camilla ViriliAbstractThe association between autoimmune atrophic gastritis and thyroid disorders has been observed since the early 1960s and the expression “thyrogastric syndrome” was coined to indicate the presence of thyroid autoantibodies or autoimmune thyroid disease in patients with pernicious anemia, a late clinical stage of autoimmune atrophic gastritis. More re...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
ConclusionsManagement of delivery in cases of suspected autosomal recessive renal polycystic kidney disease needs to be discussed because of the risk of abdominal dystocia. The route and timing of delivery depend on the size of the fetal abdominal circumference and the gestational age. The rate of kidney growth must also be taken into account.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
CONCLUSION: EDS-FLU 372 µg BID in the treatment of CRS with or without polyps was safe, well-tolerated, and produced substantial improvement across a broad range of both objective and subjective measures. PMID: 31815255 [PubMed - as supplied by publisher]
Source: Rhinology - Category: ENT & OMF Tags: Rhinology Source Type: research
Authors: Couret C, Ducloyer JB, Touhami S, Angioi-Duprez K, Rougier MB, Labalette P, Titah C, Cochereau I, Kodjikian L, Mura F, Chiquet C, Weber M, Bodaghi B Abstract Controlling long-term inflammation during non-infectious intermediate, posterior or panuveitis while limiting side effects remains challenging. There is no standardized pre-therapeutic evaluation providing diagnostic certainty, but some simple tests allow us to identifiy the main etiologies. The ophthalmologist identifies the type of uveitis, and the internist completes the investigations according to the ophthalmologist's findings. Fundus photographs...
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
Authors: Popescu IA, Statescu L, Vata D, Porumb-Andrese E, Patrascu AI, Grajdeanu IA, Solovastru LG Abstract The place of pemphigus vulgaris (PV) among autoimmune bullous dermatoses is well known. In pemphigus, IgG autoantibodies are directed against desmogleins 1 and 3, which are part of the cadherin family of cell-cell adhesion molecules. These structures are responsible for maintaining the intercellular adherence in stratified squamous epithelia, such as the skin and oral mucosa. The incidence of autoimmune bullous dermatoses is steadily increasing, being associated with a high degree of morbidity. The pathophys...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Conclusions: There is great variation among EPOS and POSNA members with regards to the diagnosis and treatment of UBCs in the humerus. Although some consensus on general treatment principles is seen, specific surgical treatment indications vary. Prospective randomized-controlled studies are needed to evaluate the outcomes of the different surgical approaches compared with nonoperative strategies. Level of Evidence: Level V—expert opinion.
Source: Journal of Pediatric Orthopaedics - Category: Orthopaedics Tags: Selected Topics Source Type: research
Roche announced today that the U.S. Food and Drug Administration (FDA) has accepted the company ’s supplemental Biologics License Application (sBLA) for Xolair® (omalizumab) for the treatment of nasal polyps in adult patients 18 years of age and older with inadequate response to intranasal corticosteroids.
Source: Roche Investor Update - Category: Pharmaceuticals Source Type: news
ConclusionComplete cytoreductive surgery is the cornerstone of the PK's management as a primary treatment. Recurrence remains common and new adjuvant strategies seem needed.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
CONCLUSION: It has been noted that thiol/disulphide homeostasis in patients with autoimmune gastritis has changed in the way that ischemia modified albumin and disulphide increased whereas thiols decreased. Altered thiol/disulphide balance was also observed in patients with delayed gastric emptying. These results have suggested that the oxidative process is involved in patients with autoimmune gastritis. PMID: 31814373 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Cushing's disease (and by extension, Cushing's syndrome) is a rare disease due to a chronic cortisol excess, which usually has an important impact on quality of life (QoL). It can lead to numerous comorbidities that can interfere with daily life, as fatigability, myopathy, bone loss and fragility, increased cardiovascular risk, depression, and cognitive alterations. Of note, psychological alterations (including depression and anxiety) occur often, and are an important determinant of impaired quality QoL. QoL scores using different questionnaires are poorer in comparison to healthy controls, other pituitary adenomas and som...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
More News: Corticosteroid Therapy | Gastritis | Gastroenteritis | Gastroenterology | Rare Diseases