Pharmacotherapy for hyperglycemia in pregnancy – Do oral agents have a place?

Gestational diabetes mellitus (GDM) is associated with short [1,2] and long term adverse outcomes for both mother [3] and offspring, throughout childhood and into adulthood [4 –7]. Long term risks for the offspring include various features of the metabolic syndrome, such as obesity, adiposity, insulin resistance and type 2 diabetes mellitus, all of which may create and intergenerational vicious cycle of metabolic derangement [8]. Hyperglycemia during pregnancy is instru mental for this perpetuation, with publications indicating its role in type 1 [9] and monogenic diabetes [10].

Source: Diabetes Research and Clinical Practice - April 18, 2018 Category: Endocrinology Authors: Rosa Corcoy, Montserrat Balsells, Apolonia Garc ía-Patterson, Anat Shmueli, Eran Hadar Tags: Review Source Type: research