An assessment of the use of antihistamines in the management of atopic dermatitis
Antihistamines are often used to treat pruritus associated with atopic dermatitis (AD) despite lack of evidence for their efficacy. The American Academy of Dermatology does not recommend the general use of antihistamines in the management of AD, although the value of short-term sedating antihistamine use for insomnia secondary to itch is recognized.
The findings of this Cochrane Review may challenge the prescribing of H1 antihistamines for patients with eczema.This Cochrane Review assessed theeffects of oral H1 antihistamines as'add-on'therapy to topical treatment in adults and children with eczema. Are H1 antihistamines taken as tablets or liquid, effective and safe in people of any age with diagnosed eczema, if given in addition to creams and ointments, compared to treatment with an inactive substance (placebo) or nothing added to creams and ointments?Eczema (also known as'atopic eczema/dermatitis') is a skin disorder frequently affecting both children and adults. I...
CONCLUSIONS: Based on the main comparisons, we did not find consistent evidence that H1 AH treatments are effective as 'add-on' therapy for eczema when compared to placebo; evidence for this comparison was of low and moderate quality. However, fexofenadine probably leads to a small improvement in patient-assessed pruritus, with probably no significant difference in the amount of treatment used to prevent eczema flares. Cetirizine was no better than placebo in terms of physician-assessed clinical signs nor patient-assessed symptoms, and we found no evidence that loratadine was more beneficial than placebo, although all inte...
CONCLUSIONS: For the following research, the authors suggest SCORAD (Total) as primary outcome and SCORAD (objective), VAS (Itch), VAS (insomnia), EASI, POEM, and DLQI as secondary outcomes. Thirty six participants should be conducted a 4-week acupuncture period (twice weekly) and a 4-week follow-up. It is necessary to compare the differences of general symptoms according to presence of epigastric tenderness or dyspepsia at the screening level. PMID: 30477869 [PubMed - in process]
This study assessed the impact of itch and pain on sleep quality among 100 patients with atopic dermatitis and 100 patients with psoriasis, compared with 50 controls. The Athens Insomnia Scale (AIS) and Pittsburgh Sleep Quality Index (PSQI) were used to evaluate a spectrum of sleep disturbances. Co-existence of insomnia was indicated in the majority of patients; atopic dermatitis (82%), psoriasis (62%). PSQI total scores for patients with atopic dermatitis (8.3 ± 4.2 points) and those with psoriasis (8.1 ± 4.8 points) qualified them, in 80% of cases, as poor sleepers and were signi...
ConclusionsSelf-reported adult-onset AD is common and has distinct phenotypes with lesional predilection for the hands and/or head/neck.
Conclusions Self-reported adult-onset AD is common and has distinct phenotypes with lesional predilection for the hands and/or head/neck.
CONCLUSIONS: Atopic dermatitis is associated with increased odds of ADD/ADHD in adults and children. Several factors increase the risk of ADHD in adults and children with AD. PMID: 27105659 [PubMed - in process]
ConclusionsAtopic dermatitis is associated with increased odds of ADD/ADHD in adults and children. Several factors increase the risk of ADHD in adults and children with AD.
ConclusionsAD is associated with increased odds ADD/ADHD in adults and children. Several factors increase the risk of ADHD in adults and children with AD.This article is protected by copyright. All rights reserved.
CONCLUSIONS: AD is associated with increased odds ADD/ADHD in adults and children. Several factors increase the risk of ADHD in adults and children with AD. This article is protected by copyright. All rights reserved. PMID: 27105659 [PubMed - as supplied by publisher]