Mutation Screening of the TIA1 Gene in Chinese Patients with Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

Mutations in the low complexity domain (LCD) of T-cell intracellular antigen-1 (TIA1) have been reported to be associated with amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD) in the Caucasian population. In the current study, we aimed to screen mutations in the LCD (exon 11-13) of TIA1 and determine the mutation frequency in Chinese ALS/FTD patients. A total of 740 ALS patients, including 721 sporadic ALS (sALS), 19 familial ALS (fALS), 24 FTD patients and 501 healthy controls (HCs), were directly sequenced.

Source: Neurobiology of Aging - April 24, 2018 Category: Neuroscience Authors: XiaoJing Gu, YongPing Chen, QianQian Wei, Bei Cao, RuWei Ou, XiaoQin Yuan, YanBin Hou, LingYu Zhang, Hui Liu, XuePing Chen, Hui-Fang Shang Tags: Brief communication Source Type: research