Presence and amount of gut bacteria can predict how fast pancreatic cancer cells grow

(Natural News) Pancreatic ductal adenocarcinoma, or PDA, is the most common and by far the most lethal form of pancreatic cancer. Pancreapedia reports that it is extremely aggressive, and for most patients their only hope of survival hinges on the total surgical removal of the tumor. Unfortunately, such tumors cannot be removed in upwards of...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news

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Objective: Although the prognostic significance of systematic inflammation-based scores, such as the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), and the prognostic nutritional index (PNI), have been explored in pancreatic cancers, few reports have investigated the lymphocyte-to-monocyte ratio (LMR). We aimed to retrospectively investigate the prognostic value of the preoperative LMR in patients with resectable pancreatic head cancer (PHC). Methods: From 2005 to 2016, 165 patients underwent pancreatoduodenectomy for PHC. All samples of peripheral blood were collected within two weeks prior ...
Source: Medical Principles and Practice - Category: Internal Medicine Source Type: research
Microbiota is just beginning to be recognized as an important player in carcinogenesis and the interplay among microbes is greater than expected. Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal dise...
Source: Molecular Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Authors: Chang Z, Zhang Y, Liu J, Guan C, Gu X, Yang Z, Ye Q, Ding L, Liu R Abstract Gemcitabine-based chemotherapy is the first-line treatment for pancreatic cancer. However, chemoresistance is a major obstacle to drug efficacy, leading to poor prognosis. Little progress has been achieved although multiple mechanisms are investigated. Therefore, effective strategies are urgently needed to overcome drug resistance. Here, we demonstrate that the transcription factor GATA binding protein 1 (GATA1) promotes gemcitabine resistance in pancreatic cancer through antiapoptotic pathway. GATA1 is highly expressed in pancreat...
Source: Journal of Oncology - Category: Cancer & Oncology Tags: J Oncol Source Type: research
Contributors : Xudong Huang ; Dongxin LinSeries Type : Expression profiling by array ; Non-coding RNA profiling by arrayOrganism : Homo sapiensGene expression profiling of pancreatic cancer cell CFPAC-1 when BACH1 knockdown. BACH1 is a transcription repressor and its regulation networks is poorly understood in pancreatic ductal adenocarcinoma. We used the total RNA from shControl and shBACH1 CFPAC-1 cells to analyze the differentially expressed genes which were regulated by BACH1, and further explored the biological processes that BACH1 may involved.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Non-coding RNA profiling by array Homo sapiens Source Type: research
Here, we describe a case of minor papillary adenocarcinoma in adenoma that was treated with endoscopic mucosal resection (EMR). In a 67-year-old woman, sigmoid colon cancer was incidentally detected on preoperative upper gastrointestinal endoscopy. Endoscopy revealed a slightly elevated lesion at the minor duodenal papilla. The findings of a histopathologic examination were suggestive of adenocarcinoma. Computed tomography and magnetic resonance images identified a minute tumor, whereas endoscopic ultrasonography revealed that the tumor did not spread to the pancreas. We performed EMR of this lesion. There were no complica...
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research
Only a few patients with pancreatic ductal adenocarcinoma (PDAC) recurring after curative resection and peri-operative (neoadjuvant and adjuvant) therapy are included in clinical trials of metastatic PDAC. As ...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
ConclusionCurrently, patients with non-metastatic borderline resectable and locally advanced pancreatic ductal adenocarcinoma are brought to diagnostic laparotomy in the absence of overt radiologic progression after neoadjuvant therapy. Apart from morphologic patterns, ongoing research is focused on defining robust functional imaging parameters for response assessment.
Source: European Surgery - Category: Surgery Source Type: research
AbstractPurpose of ReviewDespite all efforts, pancreatic ductal adenocarcinoma (PDAC) remains a disease that causes substantial morbidity and mortality, with a 5-year survival rate of 7%. Innovative paradigms for treating PDAC are urgently needed.Recent FindingsWe discuss the advances and difficulties in using immunotherapy and developing immunotherapeutic vaccines for PDAC. Current excitement about antigen-specific immunotherapy has been propelled by advances in multiple areas, such as next-generation sequencing to identify neoantigens and manufacturing to produce immunotherapeutic vaccines. Antigen-specific immunotherapy...
Source: Current Oncology Reports - Category: Cancer & Oncology Source Type: research
Publication date: Available online 15 May 2019Source: European Journal of Surgical OncologyAuthor(s): Sri Harsha Tella, Anuhya Kommalapati, Siddhartha Yadav, John R. Bergquist, Mark J. Truty, Lori Durgin, Wen Wee Ma, Sean P. Cleary, Robert R. McWilliams, Amit MahipalAbstractObjectivesSquamous cell carcinoma (SCC) of pancreas is rare entity with poorly defined prognostic factors and therapeutic outcomes. We sought to determine the overall survival (OS) and prognostic factors of patients with pancreatic SCC using National Cancer Database (NCDB) (2004–15).MethodsKaplan-Meier method and log-rank test were used to perform...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Source: Anti-Cancer Agents in Medicinal Chemistry - Category: Cancer & Oncology Authors: Tags: Review article Source Type: research
More News: Adenocarcinoma | Cancer | Cancer & Oncology | Pancreas | Pancreatic Cancer