Pituitary Diseases and Bone.

Pituitary Diseases and Bone. Endocr Rev. 2018 Apr 19;: Authors: Mazziotti G, Frara S, Giustina A Abstract Neuroendocrinology of bone is a new area of research based on the evidence that pituitary hormones may directly modulate bone remodeling and metabolism. Skeletal fragility associated with high risk of fractures is a common complication of several pituitary diseases such as hypopituitarism, Cushing disease, acromegaly and hyperprolactinemia. As in other forms of secondary osteoporosis, pituitary diseases generally affect bone quality more than bone quantity and fractures may occur even in the presence of normal or low-normal bone mineral density as measured by dual-energy X-ray absorptiometry, making difficult the prediction of fractures in these clinical settings. Treatment of pituitary hormone excess and deficiency generally improves skeletal health, although some patients remain at high risk of fractures and treatment with bone-active drugs may become mandatory.Aim of this review will be to discuss the physiological, pathophysiological and clinical insights of the bone involvement in pituitary diseases. PMID: 29684108 [PubMed - as supplied by publisher]
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research