Correlation of High-Risk Soft Tissue Sarcoma Biomarker Expression Patterns with Outcome following Neoadjuvant Chemoradiation.

Conclusions: PRE biomarker expression did not predict survival outcomes. Expression pattern changes after neoadjuvant chemoradiation supports the concepts of tumor reoxygenation, altered HIF-1α signaling, and a p53 nuclear accumulation DNA damage response. Clinical Trial Registration: NRG Oncology RTOG 9514 is registered with ClinicalTrials.gov. The ClinicalTrials.gov Identifier is NCT00002791. PMID: 29681762 [PubMed]

https://www.ncbi.nlm.nih.gov/pubmed/29681762?dopt=Abstract

Source: Sarcoma - April 25, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research