Development of next generation hemagglutinin-based broadly protective influenza virus vaccines.

Development of next generation hemagglutinin-based broadly protective influenza virus vaccines. Curr Opin Immunol. 2018 Apr 19;53:51-57 Authors: Nachbagauer R, Palese P Abstract Influenza viruses are a severe threat to human health and current vaccines do not provide sufficient protection. The highly variable nature of influenza viruses has made the production of efficacious vaccines a challenge. In recent years, a multitude of novel, broadly reactive influenza virus vaccination approaches have been described. What has long seemed impossible could now become reality in the near future-a new generation of influenza virus vaccines that provides long-lasting and broad protection against seasonal as well as potentially pandemic influenza virus strains. This review will discuss new hemagglutinin-based vaccines and their current stage of development. PMID: 29680576 [PubMed - as supplied by publisher]
Source: Current Opinion in Immunology - Category: Allergy & Immunology Authors: Tags: Curr Opin Immunol Source Type: research