Osteoblast response to Vitamin D3 loaded cellulose enriched hydroxyapatite Mesoporous silica nanoparticles composite

In this study we synthesizd a Cholecalciferol (VD3) loaded, cellulose functionalized hydroxyapatite nanocomposites with different concentration of Mesoporous silica nanoparticles (MSNs). VD3 plays an important role in the bone formation by regulating extracellular levels of calcium and phosphorus. FTIR, SEM, TEM, and X-ray diffraction techniques were used for the characterization of the prepared composites. VD3 releases from the VD3/C/HAP/MSN scaffold were observed by using UV–vis spectroscopy. The nanocomposites C/HAP/MSN, VD3/C/HAP/MSN showed higher viability compared with pure HAP and in-vitro studies revealed that the materials has enhanced the proliferative, adhesion, osteoinductive effects ALP activity and calcium deposition assay on osteoblasts like cells (MG63). Our outcome recommended that the 3D like VD3 loaded C/HAP/MSN nanocomposite scaffolds have a great potential as a bone tissue substitute. Graphical abstract
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research