GSE98184 Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells in vivo [RNA-Seq]

Contributors : Hyun Park ; Mira Jeong ; Margaret Goodell ; Grant ChallenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRecent epidemiological studies have shown that cancer-associated DNMT3A mutations can be detected in the blood of a large proportion of asymptotic elderly individuals. It is important to understand how these mutations provide a competitive advantage to HSCs and allow them to establish clonal dominance. Here we demonstrate that the stress of serial HSC transplantation immortalizes Dnmt3a-null HSCs.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research