Temperature dependent regioselective synthesis of aryl tetrazole amines using copper source

Publication date: Available online 24 April 2018 Source:Journal of Organometallic Chemistry Author(s): S.N. Murthy Boddapati, A. Emmanuel Kola, Surendra Babu Kesana, Hari Babu Bollikolla One pot highly efficient and simple protocol for the construction of aryl tetrazole amines via desulphurization/substitution/electro cyclization/C-N cross coupling reactions from thiourea with the use of cheap, readily available and air stable copper source as catalyst has been described. The reaction proceeds through the in situ formation of amino tetrazole followed by successive C-N cross-coupling reaction with aryl iodide. Further the temperature dependent regioselectivity in N-arylation of tetrazole amines has been described. Graphical abstract

Source: Journal of Organometallic Chemistry - April 24, 2018 Category: Chemistry Source Type: research