Parkin mediates mitophagy during beige-to-white fat conversion

In this issue of Science Signaling, Lu et al. reveal a role for Parkin-mediated mitophagy in beige-to-white adipocyte transition. In the absence of Parkin, mitochondria in thermogenic beige adipocytes are preserved even after the elimination of cold mimetic stimuli—in contrast to their typical elimination during the white transition.
Source: Signal Transduction Knowledge Environment - Category: Science Authors: Tags: STKE Focus Source Type: news