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Linear Link for Physical Activity, Amyotrophic Lateral Sclerosis

TUESDAY, April 24, 2018 -- There is a linear correlation for physical activity (PA) with amyotrophic lateral sclerosis (ALS), according to a study published online April 23 in the Journal of Neurology, Neurosurgery&Psychiatry. Anne E. Visser,...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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Patients with amyotrophic lateral sclerosis (ALS) who are hypermetabolic show greater functional decline and shorter survival, according to Australian researchers.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news
Reka P. Toth, Julie D. Atkin
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
(Trinity College Dublin) Scientists have just discovered that a small region of a cellular protein that helps long-term memories form also drives the neurodegeneration seen in Amyotrophic Lateral Sclerosis (ALS).
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
In this study, we detected AEG-1 expression in hSOD1G93A-positive (mut-SOD1) astrocytes and wild type (wt-SOD1) astrocytes, and intend to elucidate its potential functions in ALS related astrogliosis and the always accompanied dysregulated glutamate clearance. Results showed elevated protein and mRNA levels of AEG-1 in mut-SOD1 astrocytes; Also, NF-κB signaling pathway related proteins and inflammatory cytokines were upregulated in mut-SOD1 astrocytes; AEG-1 knockdown attenuated astrocytes proliferation and pro-inflammatory release; also we found that AEG-1 silence inhibited translocation of p65 from cytoplasma to nu...
Source: Molecular and Cellular Neuroscience - Category: Neuroscience Source Type: research
Amyotrophic lateral sclerosis (ALS) may have both spinal and bulbar manifestations, affects upper and lower limbs, resulting in respiratory insufficiency [1], difficulty gait and muscle paralysis [2]. In this way, functional alterations characterize ALS. Initially occurs in the lower limbs, progressing to the upper limbs until reaching the bulbar muscles [3]. This condition is often debilitating preventing the affected person of performing daily tasks on its own.
Source: Photodiagnosis and Photodynamic Therapy - Category: Laser Surgery Authors: Tags: Case report Source Type: research
Neurodegenerative diseases, such as Alzheimer ’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD) and amyotrophic lateral sclerosis (ALS), affect millions of people every year and so far, there...
Source: Molecular Neurodegeneration - Category: Neurology Authors: Tags: Review Source Type: research
AbstractAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease which presently does not have any efficient therapeutic approach. Pimozide, a Food and Drug Administration (FDA)-approved neuroepileptic drug, has been recently proposed as a promising treatment for ALS patients based on apparent stabilization of right hand muscles after a short-time administration. A new clinical trial started at the end of 2017 to recruit patients with a prolonged drug delivery schedule. Here, our aim was to investigate the effects of chronic administration of pimozide on disease progression and pathological events in two mo...
Source: Neurotherapeutics - Category: Neurology Source Type: research
Abstract Prion diseases are a group of neurodegenerative diseases associated with the misfolding of the cellular prion protein (PrPC) into the infectious form (PrPSc). There are currently no treatments for prion disease. Bile acids have the ability to protect hepatocytes from apoptosis and are neuroprotective in animal models of other protein folding neurodegenerative diseases including Huntington's, Parkinson's, and Alzheimer's disease. Importantly, bile acids are approved for clinical use in patients with cirrhosis, and have recently been shown to be safe and possibly effective in pilot trials of patients with a...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Establishing mechanisms of disease causation in neurodegenerative diseases has long seemed to be beyond the pale of traditional epidemiological tools. Establishing a plausible mechanism for initiation of amyotrophic lateral sclerosis (ALS) has appeared a particularly elusive goal. This review shows that a likely mechanism for ALS initiation may be inferred by applying classical methods of epidemiological inference.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Review Article Source Type: research
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that always affects the respiratory muscles. It is characterized by degeneration of motor neurons in the brain and spinal cord. Respiratory complications are the most common causes of death in ALS and typically occur within 3 to 5  years of diagnosis. Because ALS affects both upper and lower motor neurons, it causes hyperreflexia, spasticity, muscle fasciculations, muscle atrophy, and weakness. It ultimately progresses to functional quadriplegia. ALS most commonly begins in the limbs, but in about one-third of cases it begin s in the bulba...
Source: Clinics in Chest Medicine - Category: Respiratory Medicine Authors: Source Type: research
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