Exercise Intervention Doesn't Improve Walking Ability in PAD

TUESDAY, April 24, 2018 -- For patients with peripheral artery disease (PAD), a home-based exercise intervention does not improve walking ability over nine months compared with usual care, according to a study published in the April 24 issue of the...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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Conclusion Elevated concentrations of the incretin hormone GIP are found in patients with atherosclerotic cardiovascular disease, while GIP treatment attenuates atherosclerotic plaque inflammation in mice and abrogates inflammatory macrophage activation in vitro. These observations identified GIP as a counterregulatory vasoprotective peptide, which might open new therapeutic avenues for the treatment of patients with high cardiovascular risk.
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
Avinger (NSDQ:AVGR) said today it won FDA 510(k) clearance for its next-gen Pantheris lumivascular atherectomy system, which it touts as the first image-guided atherectomy device designed for treating peripheral artery disease. Redwood City, Calif.-based Avinger said the newly cleared Pantheris device features a simpler, single-balloon system designed both for apposition and blood flow occlusion and improved pushability and tissue storage capacity. The system is designed to treat blocked peripheral blood vessels, using its Lumivascular optical coherence tomography technology, the company added. “We are exci...
Source: Mass Device - Category: Medical Devices Authors: Tags: 510(k) Catheters Food & Drug Administration (FDA) Regulatory/Compliance Vascular Avinger Source Type: news
Avinger, based in Redwood City, California, just announced receiving FDA clearance for its next generation Pantheris Lumivascular atherectomy system. The product simultaneously provides intravascular imaging to allow surgeons to see the site of ...
Source: Medgadget - Category: Medical Devices Authors: Tags: Radiology Vascular Surgery Source Type: blogs
Clinical Transplantation, EarlyView.
Source: Clinical Transplantation - Category: Transplant Surgery Authors: Source Type: research
We report the clinical results of 47 high-risk patients who presented with malleolar fractures from January 2007 to December 2012 and underwent minimally invasive reduction and fixation. One patient (0.5%) developed a superficial infection; however, none of the patients displayed wound dehiscence or deep infection. Five patients (10.6%) required open reduction because of intraoperative failure to achieve anatomic reduction. Using the American Orthopaedic Foot and Ankle Society ankle-hindfoot scale, 15 of the patients (36%) treated with minimally invasive techniques experienced an excellent outcome. In contrast, 23 patients...
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
CONCLUSIONS: This is the first study to target minute-by-minute variation in TcPO2 and TcPCO2 measurements. Recording for a minimum of 15 minutes allows a reliable period for the TCOM electrode to equilibrate to record absolute values and determine wound healing potential.
Source: Advances in Skin and Wound Care - Category: Dermatology Tags: Features: Original Investigations Source Type: research
Diabetic patients exhibit distinct patterns of diffuse and recalcitrant peripheral artery disease, which subsequently predisposes them to poor wound healing, infection, and critical limb ischemia. Fatty acid synthase (FAS), an enzyme responsible for de novo fatty acid synthesis, exhibits elevated content in the liver tissue in diabetic mouse models and elevated serum levels in diabetic patients with carotid artery stenosis. It is currently unknown whether tissue FAS and serum circulating FAS (cFAS) correlate with diabetic status in patients with femoral arterial occlusive disease.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
Rates of cardiovascular and diabetes-related complications are generally decreasing. Whether a similar decline has occurred with lower extremity amputations remains poorly characterized. The aim of this study was to examine secular trends in the rate of lower extremity amputations among patients with diabetes and peripheral artery disease (PAD), within a single-payer regional health care system.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
The current “gold standard” for diagnosis of peripheral artery disease (PAD) is ankle-brachial pressure index (ABI). PAD diagnosis is complicated by vascular calcification, which causes stiff vessels and may falsely elevate ABI. Few studies have used peripheral calcium score (PCS) in lower extremity arterie s to measure PAD burden, and no studies have compared the diagnostic value of PCS with ABI. The primary aim of this study was to describe the association of PCS with continuous ABI measurements and categories of ABI in a retrospective cohort design.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
In this study, we examined perioperative outcomes of lower extremity endovascular (LEE) revascularization and open lower extremity bypass (LEB) in patients on dialysis.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
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