Prothrombin complex concentrate and fatal thrombotic adverse events: A complication to keep in mind.

We report the case of a 70 year-old male patient with cholangiocarcinoma who was admitted to our hospital with worsening fatigue and weakness. His stay was complicated by uncontrolled bleeding secondary to rivaroxaban use and advanced liver disease. By the end of the prothrombin complex concentrate infusion used to reverse his coagulopathy, patient developed ST-segment elevation myocardial infarction with cardiogenic shock and passed away. This is the first reported case of acute myocardial infarction that occurs in a patient without hemophilia and after the first prothrombin complex concentrate infusion. PMID: 29681563 [PubMed - as supplied by publisher]
Source: Drug Discoveries and Therapeutics - Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research

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Condition:   Fatty Liver Disease Intervention:   Other: A complete cardiovascular and liver characterization will be carried out Sponsors:   Instituto de Investigación Marqués de Valdecilla;   Hospital Universitario Puerta del Hierro Majadahonda.;   Hospital Universitario Ramón y Cajal;   Hospital General Universitario Gregorio Marañón Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Non-Alcoholic Fatty Liver Disease;   Non-alcoholic Fatty Liver;   Non-alcoholic Steatohepatitis Intervention:   Sponsors:   Cambridge University Hospitals NHS Foundation Trust;   The European Association for the Study of the Liver;   Children's Liver Disease Foundation Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Ischemic Cardiomyopathy Intervention:   Other: Intermittent retraining program. Sponsor:   Centre Hospitalier Universitaire de NÄ«mes Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study included 1249 consecutive patients undergoing either transcatheter aortic valve implantation (TAVI), Mitraclip, left atrial appendage occlusion (LAAO) or paravalvular leak closure (PVLC). Patients were divided into two cohorts based on the degree of probe manipulation required to guide the procedure and the risk of developing a TEE-related complication: low-risk (TAVI, n = 1037) and high-risk (Mitraclip, LAAO and PVLC, n = 212). Patients were further analyzed according to the occurrence of major and minor TEE-related complications.ResultsThe overall incidence of TEE-related complications was ...
Source: American Heart Journal - Category: Cardiology Source Type: research
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Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Source Type: blogs
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Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
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Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
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Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Abstract Hepatic dendritic cells represent a unique and multifaceted subset of antigen-presenting leukocytes that orchestrate specified immune responses in the liver. They are constantly exposed to antigens and signals derived not only from the hepatic microenvironment and the systemic circulation but also from the portal vein draining the gut and conveying food antigens as well as microbial compounds. Modulated by these various factors they shape intrahepatic immune responses during acute and chronic liver diseases, hepatocellular carcinoma and allograft tolerance as well as systemic responses to gut-derived comp...
Source: International Review of Cell and Molecular Biology - Category: Cytology Authors: Tags: Int Rev Cell Mol Biol Source Type: research
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Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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