Nestin Improves Preeclampsia-Like Symptoms by Inhibiting Activity of Cyclin-Dependent Kinase 5

Conclusions: Our findings suggest that Nestin could improve preeclampsia-like symptoms by inhibiting the activity of CDK5, and Nestin may become a new prognostic factor and a potential therapy target for PE.Kidney Blood Press Res 2018;43:616 –627
Source: Kidney and Blood Pressure Research - Category: Urology & Nephrology Source Type: research

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Publication date: Available online 31 December 2018Source: Pregnancy HypertensionAuthor(s): Jussara Leiko Sato Tebet, Gianna Mastroianni Kirsztajn, Thais Alquezar Facca, Sonia K. Nishida, Amelia Rodrigues Pereira, Silvia Regina Moreira, José Osmar Pestana Medina, Nelson SassAbstractObjectivesWe aimed to evaluate laboratory markers in women who got pregnant after renal transplantation.Study designCross-sectional prospective studyMain outcome measuresRenal function parameters and maternal and fetal data were assessed in renal transplant recipients.ResultsForty-three women who got pregnant after renal transplantation (...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Although clinical management of HELLP syndrome is similar to PE, hypertension and proteinuria do not always occur with HELPP. Thus, it was suggested that HELLP and PE could be separate clinical entities. Based on the ability of the urine misfolded proteins to retain Congo red (congophilia) it was suggested PE is a protein conformational disorder similar to Alzheimer ’s disease. Molecular diagnostics are becoming more often part of modern clinical medicine. Here we used state of the art shotgun proteomics and targeted multiple reaction monitoring (MRM) mass spectrometry to discover and validate molecular signatures in...
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Oral Concurrent 9 Source Type: research
In conclusion, measurement of the sFlt-1/PlGF ratio may be clinically useful to discriminate lupus nephritis from preeclampsia.
Source: CEN Case Reports - Category: Urology & Nephrology Source Type: research
Publication date: Available online 10 December 2018Source: Pregnancy HypertensionAuthor(s): Leticia G. Paula, Bartira E. Pinheiro da Costa, Marta R. Hentschke, Ivan C. Antonello, Jorge H. Luz, Edson V. da Cunha Filho, Carlos E. Poli-de-FigueiredoAbstractObjectivesEclampsia results in high morbidity and mortality, so it is important to identify clinical and laboratorial aspects that may be useful as potential markers to differentiate women at higher risk. Thus, we aim to identify, among women with preeclampsia, aspects that may increase the risk to develop eclampsia.Study designRetrospective cohort study. The records of pat...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
AbstractPreeclampsia, a major disorder of human pregnancy, manifests as persistent hypertension and proteinuria presenting after 20  weeks of pregnancy. Multiple systemic symptoms might be associated with preeclampsia including thrombocytopenia, liver impairment, pulmonary edema, and cerebral disturbances. However, vascular dysfunction remains the core pathological driver of preeclampsia. Defective placental implantation follow ed by dysfunctional placental spiral artery development promotes a hypoxic environment. Massive endothelial dysfunction characterized by reduced vasodilation, augmented vasoconstriction, and in...
Source: Microcirculation - Category: Research Authors: Tags: INVITED REVIEW Source Type: research
In this study, we first elucidate the role of miR‐548c‐5p and its underlying molecular mechanism in preeclampsia. Compared with healthy controls, miR‐548c‐5p was obviously downregulated in serum exosomes and placental mononuclear cells in patients with preeclampsia. Nonetheless, PTPRO was significantly upregulated and negatively associated with miR‐548c‐5p in placental mononuclear cells in patients with preeclampsia. PTPRO was a target of miR‐548c‐5p. PTPRO was downregulated in the miR‐548c‐5p‐overexpressed macropha ges. In addition, miR‐548c‐5p could inhibit the proliferation and activation of LP...
Source: Journal of Cellular Physiology - Category: Cytology Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Publication date: Available online 8 November 2018Source: Life SciencesAuthor(s): M.A. Avila-Ramírez, R.L. Esteban-Martínez, E. López-Moctezuma, L. Anguiano-Robledo, M.E. Hernández-Campos, P. López-SánchezAbstractAimsPregnancy is a physiological stage with profound cardiovascular changes leading to hypotension. Preeclampsia (PE) reverts these normal changes inducing hypertension. Renin-angiotensin system (RAS) has been related in PE genesis. It has been reported a novel receptor in the system, the Prorenin/Renin receptor (PRR), with several roles in renal and cardiovascular illness...
Source: Life Sciences - Category: Biology Source Type: research
Authors: Tayyar AT, Tayyar A, Kozali S, Karakus R, Eser A, Abide Yayla C, Yalcin ET, Dag I, Eroglu M Abstract OBJECTIVE: To investigate sestrin 2 (SESN2) levels in preeclampsia (PE) cases and uncomplicated pregnancies. METHODS: Cross-sectional study including 26 pregnant women with PE, 24 with severe-PE, and 30 randomly selected healthy pregnant women. RESULTS: The mean arterial pressure, severe proteinuria, number of HELLP syndrome cases, and serum SESN2 levels in the severe PE group were significantly higher than those in the other groups (p 
Source: Hypertension in Pregnancy - Category: OBGYN Tags: Hypertens Pregnancy Source Type: research
Publication date: Available online 2 November 2018Source: Pregnancy HypertensionAuthor(s): Ankita Malik, Babban Jee, Satish Kumar GuptaAbstractPreeclampsia is the cause of significant maternal and fetal mortality and morbidity. It is characterized by new-onset hypertension and proteinuria after 20 weeks of gestation. Preeclamptic women and children born from preeclamptic pregnancies are at greater risk to develop severe cardiovascular complications and metabolic syndromes later in life. The incidence of preeclampsia is estimated to be seven times higher in developing countries as compared to the developed countries. This r...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Publication date: Available online 2 November 2018Source: Pregnancy HypertensionAuthor(s): Thomas P. Bernardes, Ben W. Mol, Anita C.J. Ravelli, Paul P. van den Berg, H. Marike Boezen, Henk GroenAbstractObjectiveTo estimate preeclampsia occurrence and recurrence risk in the 2nd pregnancy and analyze associated risk factors such as 1st pregnancy maximum diastolic blood pressure (maxDBP) and gestational age at delivery (GA).Study DesignLinked cohort of 1st and 2nd pregnancies of 272,551 women from the Dutch Perinatal Registry collected between 2000 and 2007. We defined preeclampsia as hypertension (maxDBP ≥ 90 mmHg or docu...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
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