George H.W. Bush Hospitalized Due to Blood Infection

Bush has a form of Parkinson's disease and uses a wheelchair and electric scooter. In recent years, he has been hospitalized several times for respiratory problems, the AP reported.
Source: WebMD Health - Category: Consumer Health News Source Type: news

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Authors: Weintraub D, Mamikonyan E Abstract Affective disorders, cognitive decline, and psychosis have long been recognized as common in Parkinson disease (PD), and other psychiatric disorders include impulse control disorders, anxiety symptoms, disorders of sleep and wakefulness, and apathy. Psychiatric aspects of PD are associated with numerous adverse outcomes, yet in spite of this and their frequent occurrence, there is incomplete understanding of epidemiology, presentation, risk factors, neural substrate, and management strategies. Psychiatric features are typically multimorbid, and there is great intra- and i...
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
Conditions:   Parkinson Disease;   Osteoporosis Interventions:   Drug: Zoledronic Acid 5Mg/Bag 100Ml Inj;   Other: Placebo Sponsors:   California Pacific Medical Center Research Institute;   National Institute on Aging (NIA);   University of California, San Francisco;   Duke University;   University of Pittsburgh;   Parkinson's Foundation Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Publication date: Available online 22 April 2019Source: Stem Cell ResearchAuthor(s): Han-I Lin, Yu-Che Cheng, Hui-Wen Ko, Cheng-Hao Wen, Huai-En Lu, Ching-Ying Huang, Patrick C.H. Hsieh, Chin-Hsien LinAbstractLeucine rich repeat kinase 2 (LRRK2) is the causative gene for autosomal-dominant familial forms of Parkinson's disease (PD). Here, we generated induced pluripotent stem cells (iPSCs) from the peripheral blood mononuclear cells of a female patient with LRRK2 c.4111A > G (p.I1371V) mutation by using the Sendai-virus delivery system. The resulting iPSCs had a normal karyotype. The iPSCs also showed pluripotency c...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
As the collection of mobile health data becomes pervasive, missing data can make large portions of datasets inaccessible for analysis. Missing data has shown particularly problematic for remotely diagnosing and monitoring Parkinson's disease (PD) using smartphones. This contribution presents multi-source ensemble learning, a methodology which combines dataset deconstruction with ensemble learning and enables participants with incomplete data (i.e., where not all sensor data is available) to be included in the training of machine learning models and achieves a 100% participant retention rate. We demonstrate the propo...
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
A cutting-edge treatment proven to significantly restore movement to Parkinson’s sufferers is hailed as ‘beyond wildest dreams’ of researchers as once housebound patients walk again.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
AbstractNumerous attempts to develop an early diagnosis of Parkinson ’s disease (PD) by searching biomarkers in biological fluids were unsuccessful. The drawback of this methodology is searching markers in patients at the clinical stage without guarantee that they are also characteristic of either preclinical stage or prodromal stage (preclinical–prodromal stage) . We attempted to upgrade this methodology by selecting only markers that are found both in patients and in PD animal models. HPLC and RT-PCR were used to estimate the concentration of amino acids, catecholamines/metabolites in plasma and gene expressi...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
AbstractThe term proteostasis reflects the fine-tuned balance of cellular protein levels, mediated through a vast network of biochemical pathways. This requires the regulated control of protein folding, post-translational modification, and protein degradation. Due to the complex interactions and intersection of proteostasis pathways, exposure to stress conditions may lead to a disruption of the entire network. Incorrect protein folding and/or modifications during protein synthesis results in inactive or toxic proteins, which may overload degradation mechanisms. Further, a disruption of autophagy and the endoplasmic reticul...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
Parkinson's disease patient Gail Jardine can walk more freely after having a spinal implant fitted.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
Previously housebound patients are now able to walk more freely as a result of electrical stimulation to their spines. Researchers say the small trial of the treatment has gone 'beyond their wildest dreams'.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
Condition:   Parkinson Disease Interventions:   Drug: Pridopidine;   Drug: Placebo Sponsor:   Prilenia Therapeutics Development Ltd. Not yet recruiting
Source: - Category: Research Source Type: clinical trials
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