Thalidomide Reduces Hemorrhage of Brain Arteriovenous Malformations in a Mouse Model [Basic Sciences]

Conclusions—Thalidomide and lenalidomide improve mural cell coverage of bAVM vessels and reduce bAVM hemorrhage, which is likely through upregulation of Pdgfb expression.

Source: Stroke - April 23, 2018 Category: Neurology Authors: Wan Zhu, Wanqiu Chen, Dingquan Zou, Liang Wang, Chen Bao, Lei Zhan, Daniel Saw, Sen Wang, Ethan Winkler, Zhengxi Li, Meng Zhang, Fanxia Shen, Sonali Shaligram, Michael Lawton, Hua Su Tags: Angiogenesis, Animal Models of Human Disease, Cerebrovascular Malformations, Intracranial Hemorrhage Original Contributions Source Type: research