Molecules, Vol. 23, Pages 988: Sulforaphane Modulates Joint Inflammation in a Murine Model of Complete Freund ’s Adjuvant-Induced Mono-Arthritis
Molecules, Vol. 23, Pages 988: Sulforaphane Modulates Joint Inflammation in a Murine Model of Complete Freund’s Adjuvant-Induced Mono-Arthritis
Molecules doi: 10.3390/molecules23050988
Authors:
João Francisco Silva Rodrigues
Cristiane Silva e Silva
Thayanne França Muniz
Alana Fernanda de Aquino
Larissa Neuza da Silva Nina
Nagila Caroline Fialho Sousa
Luis Claudio Nascimento da Silva
Breno Glaessner Gomes Fernandes de Souza
Tatiana Aranha da Penha
Ana Lúcia Abreu-Silva
Joicy Cortez de Sá
Elizabeth Soares Fernandes
Marcos Augusto Grigolin Grisotto
Rheumatoid arthritis (RA) is characterized by inflammation of one or more joints, and affects ~1% of the adult population worldwide. Sulforaphane (SFN) is a natural compound that has been suggested as an antioxidant. Here, SFN’s effects were evaluated in a murine mono-arthritis model. Mono-arthritis was induced in mice by a single intra-articular injection of Complete Freund’s Adjuvant (CFA-10 µg/joint, in 10 µL) into the ipsilateral joint. The contralateral joint received an equal volume of PBS. On the 4th day post-joint inflammation induction, animals received either SFN (10 mg/kg) or vehicle (3% DMSO in saline), intraperitoneally (i.p.), twice a day for 3 days. Joint swelling and secondary mechanical allodynia and hyperalgesia were evaluated over 7 days post-CFA. After this period, animals were culled and their blood and synovial fluid sam...
Source: Molecules - Category: Chemistry Authors: Jo ão Francisco Silva Rodrigues Cristiane Silva e Silva Thayanne Fran ça Muniz Alana Fernanda de Aquino Larissa Neuza da Silva Nina Nagila Caroline Fialho Sousa Luis Claudio Nascimento da Silva Breno Glaessner Gomes Fernandes de Souza Tatiana Aranha da Tags: Article Source Type: research