Molecules, Vol. 23, Pages 988: Sulforaphane Modulates Joint Inflammation in a Murine Model of Complete Freund ’s Adjuvant-Induced Mono-Arthritis

Molecules, Vol. 23, Pages 988: Sulforaphane Modulates Joint Inflammation in a Murine Model of Complete Freund’s Adjuvant-Induced Mono-Arthritis Molecules doi: 10.3390/molecules23050988 Authors: João Francisco Silva Rodrigues Cristiane Silva e Silva Thayanne França Muniz Alana Fernanda de Aquino Larissa Neuza da Silva Nina Nagila Caroline Fialho Sousa Luis Claudio Nascimento da Silva Breno Glaessner Gomes Fernandes de Souza Tatiana Aranha da Penha Ana Lúcia Abreu-Silva Joicy Cortez de Sá Elizabeth Soares Fernandes Marcos Augusto Grigolin Grisotto Rheumatoid arthritis (RA) is characterized by inflammation of one or more joints, and affects ~1% of the adult population worldwide. Sulforaphane (SFN) is a natural compound that has been suggested as an antioxidant. Here, SFN’s effects were evaluated in a murine mono-arthritis model. Mono-arthritis was induced in mice by a single intra-articular injection of Complete Freund’s Adjuvant (CFA-10 µg/joint, in 10 µL) into the ipsilateral joint. The contralateral joint received an equal volume of PBS. On the 4th day post-joint inflammation induction, animals received either SFN (10 mg/kg) or vehicle (3% DMSO in saline), intraperitoneally (i.p.), twice a day for 3 days. Joint swelling and secondary mechanical allodynia and hyperalgesia were evaluated over 7 days post-CFA. After this period, animals were culled and their blood and synovial fluid sam...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research