Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium

ConclusionsThe combined effects of the 77-SNP PRS and environmental risk factors for breast cancer are generally well described by a multiplicative model. Larger studies are required to confirm possible departures from the multiplicative model for individual risk factors, and assess models specific for ER-negative disease.
Source: International Journal of Epidemiology - Category: Epidemiology Source Type: research