How a False Alarm Affects Future Cancer Screenings

MONDAY, April 23, 2018 -- A cancer scare could increase the chances that you'll be diligent about recommended screenings in the future, a new study finds. People who got a false-positive result on a breast or prostate cancer screening test were more...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news

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Abstract Oxidative stress is a primary cause of vascular endothelial damage. In the prostate, ischemia increases the levels of reactive oxygen species, growth factors and cytokines, and induces the development of angiogenesis, which results in cancer progression. The expression levels of an oxidative stress marker, 8-hydroxyguanosine (8-OHdG), were compared between prostate cancer and non-neoplastic prostate tissues. A prostate tissue microarray composed of 10 cases of prostatic adenocarcinoma and 70 cases of benign prostatic hyperplasia was immunohistochemically stained for 8-OHdG. All cases expressed 8-OHdG. The...
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Tags: Mol Clin Oncol Source Type: research
Veterans who seek care for low-risk prostate cancer receive more imaging that...Read more on AuntMinnie.comRelated Reading: Can AI best quantitative MRI in prostate lesions? Multiparametric MRI aids in prostate cancer follow-up SNMMI: Early prostate cancer therapy extends lives SNMMI: Fluciclovine-PET changes prostate treatment MRI-based risk model improves prostate cancer detection
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Condition:   Prostate Cancer Intervention:   Diagnostic Test: Fluciclovine PET/MRI Sponsor:   New York University School of Medicine Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Di Stefano C, Grazioli P, Fontanella RA, De Cesaris P, D'Amore A, Regno M, Starace D, Padula F, Fiori ME, Canipari R, Stoppacciaro A, Pesce M, Filippini A, Campese AF, Ziparo E, Riccioli A Abstract In human prostate cancer (PCa), the neuroendocrine cells, expressing the prostate cancer stem cell (CSC) marker CD44, may be resistant to androgen ablation and promote tumor recurrence. During the study of heterogeneity of the highly aggressive neuroendocrine PCa cell lines PC3 and DU-145, we isolated and expanded in vitro a minor subpopulation of very small cells lacking CD44 (CD44neg). Unexpectedly, these sort...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Dr. Daniel Goldstein summarizes key data in genitourinary oncology from ASCO 2018, including new results on pembrolizumab (Keytruda) for metastatic prostate cancer, asking whether it could find a plac... Author: BeaconMedIC Added: 08/16/2018
Source: Oncology Tube - Category: Cancer & Oncology Source Type: podcasts
The Prostate, EarlyView.
Source: The Prostate - Category: Urology & Nephrology Authors: Source Type: research
The miR-96 and RARγ signaling axis governs androgen signaling and prostate cancer progressionThe miR-96 and RARγ signaling axis governs androgen signaling and prostate cancer progression, Published online: 17 August 2018; doi:10.1038/s41388-018-0450-6The miR-96 and RARγ signaling axis governs androgen signaling and prostate cancer progression
Source: Oncogene - Category: Cancer & Oncology Authors: Source Type: research
The aim of this study was to systematically review tolerance doses for late distinct gastrointestinal, genitourinary, and sexual dysfunction (GI/GU/SD) symptoms following external-beam RT (EBRT) alone and treatments involving brachytherapy (BT ±EBRT) for prostate cancer post-QUANTEC, and to ultimately perform quantitative syntheses of identified dose/volume tolerances represented by dose-volume histogram (DVH) thresholds, i.e., statistically significant (p≤0.05) cutoff points between symptomatic and asymptomatic patients in a certain s tudy.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Physics Contribution Source Type: research
The skeleton is a common site for cancer metastases. Bone metastases are a major cause of morbidity and mortality and associated with pain, pathologic fractures, spinal cord compression, and decreased survival. Various radionuclides have been used for pain therapy. Recently, an α-emitter has been shown to improve overall survival of patients with bone metastases from castration-resistant prostate cancer and was approved as a therapeutic agent. The aim of this article is to provide an overview regarding state of the art radionuclide therapy options for bone metastases, wit h focus on the role of PET imaging in therapy planning.
Source: PET Clinics - Category: Radiology Authors: Source Type: research
In this study, we report that AR membrane transport is microtubule-dependent. Disruption of the function of kinesin 5B (KIF5B), but not of kinesin C3 (KIFC3), interfered with AR membrane association and signaling. Co-immunoprecipitation and pulldown assays revealed that AR physically interacts with KIF5B and that androgen enhances this interaction. Furthermore, we show that heat shock protein 27 (HSP27) is activated by membrane-associated AR and that HSP27 plays an important role in mediating AR-mediated membrane-to-nuclear signal transduction. Together, these results indicate that AR membrane translocation is mediated by ...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Cell Biology Source Type: research
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