How a False Alarm Affects Future Cancer Screenings

MONDAY, April 23, 2018 -- A cancer scare could increase the chances that you'll be diligent about recommended screenings in the future, a new study finds. People who got a false-positive result on a breast or prostate cancer screening test were more...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news

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Androgens such as testosterone and dihydrotestosterone are a critical driver of prostate cancer progression. Cancer resistance to androgen deprivation therapies ensues when tumors engage metabolic processes that produce sustained androgen levels in the tissue. However, the molecular mechanisms involved in this resistance process are unclear, and functional imaging modalities that predict impending resistance are lacking. Here, using the human LNCaP and C4-2 cell line models of prostate cancer, we show that castration treatment–sensitive prostate cancer cells that normally have an intact glucuronidation pathway that r...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Metabolism Source Type: research
Saurabh Pandey, Carina Walpole, Paul N. Shaw, Peter J. Cabot, Amitha K. Hewavitharana, Jyotsna Batra
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 14 November 2018Source: European Journal of RadiologyAuthor(s): Alireza Aminsharifi, Rajan T. Gupta, Efrat Tsivian, Sitharthan Sekar, Christina Sze, Thomas J. PolascikAbstractPurposeTo introduce and assess the efficacy of a reduced core targeted (RCT) biopsy template (image-targeted + laterally directed sextant biopsy) to detect clinically-significant cancer in patients with elevated PSA and a previous negative biopsy or on active surveillance. The performance and added value of either targeted alone vs random sextant vs combined biopsy template was appraised.MethodsData fro...
Source: European Journal of Radiology - Category: Radiology Source Type: research
CONCLUSIONS High-level expression of KIF22 was related to both tumor progression and adverse clinical outcome. For this reason, KIF22 may become a potential prognostic factor for PCa. PMID: 30427826 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Publication date: Available online 6 November 2018Source: Journal of Bone OncologyAuthor(s): Stella D'Oronzo, Robert Coleman, Janet Brown, Francesco SilvestrisAbstractBone metastases (BM) are a common complication of cancer, whose management often requires a multidisciplinary approach. Despite the recent therapeutic advances, patients with BM may still experience skeletal-related events and symptomatic skeletal events, with detrimental impact on quality of life and survival.A deeper knowledge of the mechanisms underlying the onset of lytic and sclerotic BM has been acquired in the last decades, leading to the development o...
Source: Journal of Bone Oncology - Category: Cancer & Oncology Source Type: research
Interview with Anthony D'Amico, MD, PhD, author of Surgery vs Radiotherapy in the Management of Biopsy Gleason Score 9-10 Prostate Cancer and the Risk of Mortality
Source: JAMA Specialty Journals Author Interviews - Category: General Medicine Source Type: podcasts
Abstract Background: Cancer survivors suffer from many comorbid conditions even after the cure of their cancers beyond 5 years. We explored the differences in the association of comorbid conditions between the cancer survivors and patients without cancer. Methods: Electronic medical records of 280 adult cancer survivors and 280 age-matched patients without cancer in our suburban internal medicine office were reviewed. Results: Mean age of the cancer survivors was 72.5 ± 13.1 years, and the age of the patients without cancer was 72.5 ± 12.8 years. The number of male cancer survivors was sign...
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Tags: J Clin Med Res Source Type: research
This article reflects the aspects that are most influential on daily practice. A brief summary of 3 ancillary commercially available genomic tests is also provided.
Source: Surgical Pathology Clinics - Category: Pathology Authors: Source Type: research
Morteza Esmaeili, Nassim Tayari, Tom Scheenen, Mattijs Elschot, Elise Sandsmark, Helena Bertilsson, Arend Heerschap, Kirsten M. Seln æs, Tone F. Bathen
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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