Both oophorectomy and obesity impaired solely hippocampal-dependent memory via increased hippocampal dysfunction.

Both oophorectomy and obesity impaired solely hippocampal-dependent memory via increased hippocampal dysfunction. Exp Gerontol. 2018 Apr 17;: Authors: Mantor D, Pratchayasakul W, Minta W, Sutham W, Palee S, Sripetchwandee J, Kerdphoo S, Jaiwongkum T, Sriwichaiin S, Krintratun W, Chattipakorn N, Chattipakorn SC Abstract Our previous study demonstrated that obesity aggravated peripheral insulin resistance and brain dysfunction in the ovariectomized condition. Conversely, the effect of obesity followed by oophorectomy on brain oxidative stress, brain apoptosis, synaptic function and cognitive function, particularly in hippocampal-dependent and hippocampal-independent memory, has not been investigated. Our hypothesis was that oophorectomy aggravated metabolic impairment, brain dysfunction and cognitive impairment in obese rats. Thirty-two female rats were fed with either a normal diet (ND, n = 16) or a high-fat diet (HFD, n = 16) for a total of 20 weeks. At week 13, rats in each group were subdivided into sham and ovariectomized subgroups (n = 8/subgroup). At week 20, all rats were tested for hippocampal-dependent and hippocampal-independent memory by using Morris water maze test (MWM) and Novel objective recognition (NOR) tests, respectively. We found that the obese-insulin resistant condition occurred in sham-HFD-fed rats (HFS), ovariectomized-ND-fed rats (NDO), and ovariectomized-HFD-fed rats (HFO). Increased hippocampal...
Source: Experimental Gerontology - Category: Geriatrics Authors: Tags: Exp Gerontol Source Type: research