Low dose of acacetin promotes breast cancer MCF-7 cells proliferation through the activation of ERK/ PI3K /AKT signaling pathway.

Conclusion Low dose of acacetin from 10^-3 μM to 1 μM promoted the proliferation of MCF-7 cells through the ERK/PI3K/AKT pathway and its downstream cyclin signaling, and this pathway is mainly mediated by the expression of ERα. PMID: 29676234 [PubMed - as supplied by publisher]
Source: Recent Patents on Anti-Cancer Drug Discovery - Category: Cancer & Oncology Tags: Recent Pat Anticancer Drug Discov Source Type: research