Increased fibulin-1 plasma levels in polycystic ovary syndrome (PCOS) patients: possible contribution to the link between PCOS and cardiovascular risk

ConclusionsOur data could contribute to explain the hypothesized increased cardiovascular risk and vascular damage in patients with PCOS. A better understanding of the cellular and molecular mechanisms involved in cardiometabolic disorders associated with PCOS is mandatory to identify new therapeutic strategies to eventually prevent the progression of cardiovascular diseases in these patients.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research

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Publication date: Available online 5 September 2018Source: Journal of EthnopharmacologyAuthor(s): Madeleine Ong, Jing Cheng, Xingliang Jin, Weiguo Lao, Michael Johnson, Yi Tan, Xianqin QuAbstractEthnopharmacological relevancePolycystic Ovarian Syndrome (PCOS) is a complex endocrine and reproductive disorder. A main hallmark includes increased androgen production. The root of Paeonia lactiflora Pall. (Bai Shao) is used in Chinese herbal medicine for reproductive disorders, however its effects and mechanisms on ovarian theca cells has not yet been fully elucidated.Aim of the studyThe aim of this study was to evaluate effect ...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 29 August 2018Source: Reproductive BioMedicine OnlineAuthor(s): Liangshan Mu, Yue Zhao, Rong Li, Yuchen Lai, Jie QiaoAbstractResearch question: The aim was to investigate the metabolic profiles of women with normal weight but central obesity in polycystic ovary syndrome (PCOS).Design: In total, 727 women with PCOS from a large-scale epidemiological survey were included. Diagnosis of PCOS was based on Rotterdam criteria. Subjects were categorized into four subgroups: (i) normal weight non-central obesity (NWNCO): body mass index (BMI) ≤18.5 kg/m2 to
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
ConclusionPrenatal exposure to metformin is associated with increased offspring weight, but not with height or BMI. Larger follow-up studies are needed to confirm and look into the implications of these findings.Plain Language SummaryPlain language summary available for this article.
Source: Diabetes Therapy - Category: Endocrinology Source Type: research
This study aimed at evaluating galectin-3 levels as a novel metabolic biomarker in women with PCOS.MethodsNinety consecutive women with PCOS fulfilling the inclusion criteria were divided into two groups according to the presence of metabolic syndrome as MetS+ and MetS −. Clinical, hormonal, and metabolic parameters and galectin-3 levels were compared between the groups. Correlation analyses were performed between galectin-3 and clinical and metabolic parameters.ResultsNinety PCOS subjects were enrolled in the study, 25 of which were diagnosed with MetS. Waist-to-hip ratio, systolic and diastolic blood pressures, tri...
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
ConclusionsThe results of the present study revealed that the genes variants RBP4 is not associated with PCO. It seems that rs1501299 of ADIPOQ gene influences the occurrence of PCO and lipids profile in those patients.
Source: Advances in Medical Sciences - Category: Biomedical Science Source Type: research
ConclusionThis study showed that vitamin D replacement in women with PCOS and vitamin D deficiency has no effect on the improvement of metabolic parameters and HOMA-IR.
Source: Middle East Fertility Society Journal - Category: Reproduction Medicine Source Type: research
ConclusionSerum visfatin levels could discriminate PCOS from healthy control and T2DM from NGT PCOS women. Moreover, vesfatin was positive correlated to cardio-metabolic risk factors. Interestingly, the sensitivity and specificity power of vesfatin were high. Thus, it could be early predicting of cardio-metabolic risks among PCOS women and might be useful in therapeutic intervention in future.
Source: Middle East Fertility Society Journal - Category: Reproduction Medicine Source Type: research
Publication date: May 2018Source: Diabetes &Metabolic Syndrome: Clinical Research &Reviews, Volume 12, Issue 3Author(s): Muhammad Bilal, Abdul Haseeb, Abdur RehmanAbstractBackgroundPolycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting women of reproductive age. The two main documented pathogenic mechanisms are hyperinsulinemia and hyperandrogenemia but there is growing evidence for increased predisposition to cardiovascular disease, dyslipidemia, and type 2 diabetes mellitus. Our study aims to analyze the association of PCOS with cardiovascular risk factors.MethodsThis is a prospective st...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
ConclusionsThe results of the present study revealed that the genes variants RBP4 is not associated with PCO. It seems that rs1501299 of ADIPOQ gene influences the occurrence of PCO and lipids profile in those patients.
Source: Advances in Medical Sciences - Category: Biomedical Science Source Type: research
ConclusionThis study showed that vitamin D replacement in women with PCOS and vitamin D deficiency has no effect on the improvement of metabolic parameters and HOMA-IR.
Source: Middle East Fertility Society Journal - Category: Reproduction Medicine Source Type: research
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