Oral and sublingual immunotherapy for egg allergy.

CONCLUSIONS: Frequent and increasing exposure to egg over one to two years in people who are allergic to egg builds tolerance, with almost everyone becoming more tolerant compared with a minority in the control group and almost half of people being totally tolerant of egg by the end of treatment compared with 1 in 10 people who avoid egg. However, nearly all who received treatment experienced adverse events, mainly allergy-related. We found that 1 in 12 children had serious allergic reactions requiring adrenaline, and some people gave up oral immunotherapy. It appears that oral immunotherapy for egg allergy is effective, but confidence in the trade-off between benefits and harms is low; because there was a small number of trials with few participants, and methodological problems with some trials. PMID: 29676439 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research

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(MedPage Today) -- Immunotherapy, cannabis, antibiotic stewardship will also be discussed
Source: MedPage Today Allergy - Category: Allergy & Immunology Source Type: news
ia JL Abstract Allergen-specific immunotherapy (AIT) is the only treatment that may affect the natural course of allergic diseases such as allergic asthma, allergic rhinitis, and IgEmediated food allergy. Adjuvants are used to induce a quicker, more potent, and longer-lasting AIT immune response. Up to now, only four compounds are used as adjuvants in currently marketed AIT products: aluminum hydroxide, calcium phosphate, microcrystalline tyrosine (MCT), and monophosphoryl lipid A (MPL). The three first adjuvants are delivery systems with depot effect, although they also may have immunomodulatory properties. These...
Source: Journal of Investigational Allergology and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: J Investig Allergol Clin Immunol Source Type: research
Over the last decade much attention has focused on the possibility of using oral immunotherapy (OIT) as a therapeutic approach for treatment of IgE-mediated food allergies, a disease without a Food and Drug Administration (FDA)-approved disease-modifying therapy. Peanut allergy has been a particular concern because of its persistent nature and association with potentially life-threatening reactions. The OIT literature has been criticized for heterogeneity in trial design with disparities in identification of allergic individuals by double blind placebo controlled food challenges (DBPCFC), differences in desensitization app...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
Purpose of review This review examines the current literature and provides insight into the role of food immunotherapy in the management of food-allergic children. Key food immunotherapy trials, benefits, and risks of the intervention, as well as areas requiring further study are all discussed. Recent findings Research studies have reported encouraging results regarding the efficacy of food immunotherapy in desensitizing food-allergic patients with an acceptable safety profile and a documented improvement in quality of life. The role of biologics and long-term effects of food immunotherapy are still under investigatio...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: ALLERGY, IMMUNOLOGY AND RELATED DISORDERS: Edited by Henry H. Bernstein Source Type: research
More than half of wheat-allergic children could successfully consume wheat protein at 1 year, but response to oral immunotherapy was lower than for other food allergies, a small study has found.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Family Medicine/Primary Care News Source Type: news
IgE-mediated food allergy is a growing problem with no curative therapy1. Oral immunotherapy (OIT) has shown promise, but its utility is limited by reactions during treatment and a lack of sustained protection following therapy. IgE antibodies trigger hypersensitivity reactions to foods. Their effects, mediated by Fc εRI on mast cells and basophils, can be countered by IgG antibodies of shared specificity signaling via the inhibitory Fc receptor, FcγRIIb2. OIT induces only modest reductions in specific IgE antibodies but stimulates dramatic increases in inhibitory IgG3, 4.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
AbstractPurpose of reviewThe increase in IgE-mediated food allergy in the world with prevalence of egg, milk, peanut, and wheat allergies presenting and coexisting as multiple food allergies in young children.Recent findingsEarlier initiation in weaning and timing of exposure of specific food allergens to an atopic infant appears to affect the trajectory and progression of acquiring tolerance in these children for specific foods. In this review, the allergen-specific strategies for increasing tolerance (desensitization) and hastening the resolution of food allergy (SU) are reviewed for treatment of food allergy.SummaryPhen...
Source: Current Treatment Options in Allergy - Category: Allergy & Immunology Source Type: research
AbstractFood allergies are defined as adverse immune responses to food proteins that result in typical clinical symptoms involving the dermatologic, respiratory, gastrointestinal, cardiovascular, and/or neurologic systems. IgE-mediated food-allergic disease differs from non-IgE-mediated disease because the pathophysiology results from activation of the immune system, causing a T helper 2 response which results in IgE binding to Fcε receptors on effector cells like mast cells and basophils. The activation of these cells causes release of histamine and other preformed mediators, and rapid symptom onset, in contrast w...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
ConclusionReliable recommendations on the use of AIT with pollen allergens in pollen-related food allergy are not possible as yet. AIT with birch pollen allergens appears to have a  positive effect on concomitant food allergy in some patients with birch pollen allergy.
Source: Allergo Journal International - Category: Allergy & Immunology Source Type: research
Authors: de Jong NW PMID: 30295101 [PubMed - as supplied by publisher]
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
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