Sinusoidal obstruction syndrome after BeAM conditioning regiment for autologous stem cell transplantation: Imputability of bendamustine? Report of two cases and literature review.

CONCLUSION: Our observations highlight the difficulty to diagnose this complication with often non-specific clinical presentation and possible delayed occurrence after to transplantation, but also the therapeutic challenges, defibrotide being the only agent currently efficient. Physiopathology and potential responsibility of bendamustine in the sinusoidal obstruction syndrome occurrence will be discussed. PMID: 29673920 [PubMed - as supplied by publisher]
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research

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Non-Hodgkin lymphoma (NHL) is typically sensitive to conventional doses of chemotherapy but many patients do not respond to front-line treatment or subsequently relapse after achieving remission. For medically-fit patients with relapsed/refractory follicular lymphoma (FL) or diffuse large B-cell lymphoma (DLBCL), subsequent treatment with high dose chemotherapy and autologous hematopoietic stem cell transplantation (ASCT) is often indicated [1 –4]. ASCT is also performed as consolidation treatment for patients with mantle cell lymphoma (MCL) and peripheral T-cell lymphoma (PTCL) and is associated with favorable progr...
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Publication date: Available online 10 October 2019Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Forat Lutfi, William Paul Skelton, Yu Wang, Emma Rosenau, Nosha Farhadfar, Hemant Murthy, Christopher R. Cogle, Ranadall Brown, John Hiemenz, John Hiemenz, John R. Wingard, Maxim NorkinAbstractObjective/BackgroundClinical predictors of delayed engraftment following autologous hematopoietic cell transplantation (AHCT) are poorly described in the literature. The purpose of this study was to identify pretransplant characteristics contributing to delayed engraftment (DE) following AHCT.MethodsA retrospective, single in...
Source: Hematology Oncology and Stem Cell Therapy - Category: Cancer & Oncology Source Type: research
Publication date: Available online 9 October 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Joseph MikhaelAbstractThe advent of new, more effective, and less toxic therapies has revolutionized the management of multiple myeloma in the past decade. Despite the availability of new treatments, the majority of patients with multiple myeloma will become refractory to the therapies that currently comprise the hematologic standard of care for the malignancy: proteasome inhibitors, immunomodulatory agents, and monoclonal antibodies. Moreover, in recent years, a new subset of patients refractory to all 3 of these agen...
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
ConclusionOutpatient ASCT is a safe and feasible treatment strategy with low TRM. Overall resource utilization are significantly lower than inpatient auto-transplantation: however, this requires a multidisciplinary approach with close follow up
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Conditions:   Aggressive Non-hodgkin Lymphoma (aNHL);   Lymphoma, B-Cell;   Lymphoma, T-Cell Interventions:   Drug: High dose chemotherapy before allogeneic stem cell transplantation (alloSCT);   Procedure: Bone marrow histology;   Diagnostic Test: clinical and laboratory parameters;   Diagnostic Test: PET-CT or CT Sponsor:   GWT-TUD GmbH Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 9 October 2019Source: The Journal of Molecular DiagnosticsAuthor(s): Zohair Siddiqui, Juan Maldonado, Jeremy Grojean, Fei Ye, David Zhang, Janina Longtine, Tae-Hyuk Ahn, Huazhang GuoAbstractA quantitative chimerism test monitors engraftment of donor hematopoietic stem cells or relapse of leukemias or lymphomas in hematopoietic stem cell transplantation patients. The most common method used for chimerism testing is PCR amplification of short tandem repeat loci followed by capillary gel electrophoresis. Manual data analysis is tedious and time consuming, as it involves the selection of info...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
Authors: Seidel S, Schlegel U Abstract Introduction: Primary CNS lymphomas (PCNSL) are highly aggressive tumors and optimal treatment is not yet defined. For the last two decades clinical trials have focused on developing efficient chemotherapy protocols with or without dose reduced radiation to avoid late cognitive decline after whole brain radiotherapy (WBRT). Areas covered: This review addresses the question if these substantial developments have led to clinically relevant therapeutic improvement for PCNSL within the last decade. Expert opinion: The high risk of neurotoxic side effects of WBRT was further substa...
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
ix H, Duarte RF, Basak GW Abstract Uric acid is a danger signal contributing to inflammation. Its relevance to allogeneic stem cell transplantation derives from preclinical models where the depletion of uric acid led to improved survival and reduced graft-versus-host disease. In a clinical pilot trial, peri-transplant uric acid depletion reduced acute graft-versus-host disease incidence. This prospective international multicenter study aimed to investigate the association of uric acid serum levels before start of conditioning with allogeneic stem cell transplantation outcome. We included patients with acute leukem...
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research
This study emphasizes the feasibility of ASCT in an outpatient model of care and outlines the resources necessary to run such a unit.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research
A quantitative chimerism test monitors engraftment of donor hematopoietic stem cells or relapse of leukemias or lymphomas in hematopoietic stem cell transplantation patients. The most common method used for chimerism testing is PCR amplification of short tandem repeat loci followed by capillary gel electrophoresis. Manual data analysis is tedious and time consuming, as it involves the selection of informative loci and the repetition of quantifying chimerism percentage for multiple loci from multiple cell types.
Source: Journal of Molecular Diagnostics - Category: Pathology Authors: Tags: Technical Advance Source Type: research
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