Older Subjects with β-cell Dysfunction have an Accentuated Incretin Release.

Conclusions: Aging is associated with an exaggerated GLP-1 secretory response. However, this was not sufficient to increase insulin first phase release in O-IGT and overcome insulin resistance.
PMID: 29672742 [PubMed - as supplied by publisher]

Source: The Journal of Clinical Endocrinology and Metabolism - April 16, 2018 Category: Endocrinology Authors: Garduno-Garcia JJ, Gastaldelli A, DeFronzo RA, Lertwattanarak R, Holst JJ, Musi N Tags: J Clin Endocrinol Metab Source Type: research