Tanshinone IIA suppresses Fc εRI-mediated mast cell signaling and anaphylaxis by activation of the Sirt1/LKB1/AMPK Pathway.

In conclusion, Tan IIA suppresses FcεRI-mediated mast cell activation and anaphylaxis through activation of the inhibitory Sirt1-LKB1-AMPK pathway. Thus, Tan IIA may be useful as a new therapeutic agent for mast cell-mediated allergic diseases.
PMID: 29674003 [PubMed - as supplied by publisher]

Source: Biochemical Pharmacology - April 16, 2018 Category: Drugs & Pharmacology Authors: Li X, Park SJ, Jin F, Deng Y, Yang JH, Chang JH, Kim DY, Kim JA, Lee YJ, Murakami M, Son KH, Chang HW Tags: Biochem Pharmacol Source Type: research