Circulating Soluble Receptor Activator of Nuclear Factor Kappa B Ligand and C-C Motif Ligand 3 Correlate With Survival in Patients With Waldenstr öm Macroglobulinemia

We reviewed 55 patients with untreated symptomatic Waldenstr öm macroglobulinemia (WM) and prospectively evaluated their serum cytokines and biological markers. High circulating chemokine (C-C) motif ligand 3 (CCL-3) serum levels predicted shorter progression-free survival while high serum receptor activator of nuclear factor κB ligand levels predicted shor ter overall survival. This correlation reveals the importance of these cytokines in disease biology and highlights the significance of the interactions between WM and stromal cells for the development of WM.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research