Cancers, Vol. 10, Pages 125: Selective Inhibition of Histone Deacetylation in Melanoma Increases Targeted Gene Delivery by a Bacteriophage Viral Vector

We report that the HDAC inhibitor C1A increased AAVP-mediated transgene expression by up to ~9-fold. These findings indicate that selective HDAC inhibition is a promising adjuvant treatment for increasing the therapeutic value of AAVP.

Source: Cancers - April 21, 2018 Category: Cancer & Oncology Authors: Samuel Campbell Keittisak Suwan Sajee Waramit Eric Ofori Aboagye Amin Hajitou Tags: Brief Report Source Type: research