Surgical Management of Head and Neck Soft Tissue Sarcoma: 11-Year Experience at a Tertiary Care Centre in South India
This study aimed at analysing clinicopathological, recurrence and survival pattern of surgically treated HNSTS. Case records of 28 patients of HNSTS who underwent surgery at the Regional Cancer Centre (RCC), Trivandrum (India) between 2002 and 2012 were analysed retrospectively for demographic profile, clinical features, treatment given, recurrence pattern and outcome. The median age of patients was 37 years (range, 3–79) with male:female ratio of 3:2. Majority of patients presented with painless lump in the neck as the most common subsite affected followed by scalp and face. One patient had nodal disease, while none had distant metastasis at presentation. The most frequent histological subtyp es were synovial sarcoma and fibrosarcoma followed by malignant fibrous histiocytoma, angiosarcoma and rhabdomyosarcoma. Majority (78.5%) of patients received adjuvant therapy in the form of radiation, chemotherapy or chemo-radiation. After mean follow-up of 49 months, four patients had died, and s ix developed local recurrence and four distant metastasis. The overall 5-year survival was 82.7% while 5-year disease-free survival was 55.3%. HNSTS is a rare entity that requires multimodality treatment to achieve optimum locoregional control and survival.
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Publication date: Available online 20 June 2020Source: The Journal of Molecular DiagnosticsAuthor(s): Lynette M. Sholl, Diana Mandelker, Tracy Stockley
Publication date: Available online 13 July 2020Source: Pathology - Research and PracticeAuthor(s): Jie Zhang, Sujie Zhang, Xiaoyan Li, Fan Zhang, Lei Zhao
Publication date: Available online 13 July 2020Source: Pathology - Research and PracticeAuthor(s): Xianglin Yang, Xuelian Li, Xia Hao, Wen Tian, Baosen Zhou
Publication date: Available online 13 July 2020Source: Pathology - Research and PracticeAuthor(s): Yu-Peng Wu, Zhi-Bin Ke, Fei Lin, Yao-An Wen, Sheng Chen, Xiao-Dong Li, Shao-Hao Chen, Xiong-Lin Sun, Jin-Bei Huang, Qing-Shui Zheng, Xue-Yi Xue, Yong Wei, Ning Xu
Publication date: Available online 13 July 2020Source: Pathology - Research and PracticeAuthor(s): Leonardo Franz, Lara Alessandrini, Giancarlo Ottaviano, Roberto di Carlo, Elena Fasanaro, Giulia Ramacciotti, Giacomo Contro, Gino Marioni
Probiotics are living microorganisms, which when taken in adequate amount, provide various health benefits by maintaining the balance of bacteria in the intestine. Probiotics are purported to have countless health benefits, some of which include improved digestion, enhanced immunity, prevention of cancer and diabetes. The most common group of probiotics include species of Lactobacillus, Bifidobacterium and Enterococcus. In order to work as an effective probiotic, the microbial strain is expected to exhibit certain desirable characteristics like acid and bile tolerance, antimicrobial activity, adhesion to intestinal epithel...
Conclusion: The detailed research on the patent information presented herein focused on the activity of the compositions containing jackfruit extract and isolated phytochemicals would assist researchers to understand the mechanisms by which the bio-chemicals exert their effect and the overall nutritional benefits. An increase in the number of publications and patents in recent years related to the use of jackfruit for different health conditions clearly emphasizes its therapeutic potential and importance as medicinal food products and cosmetics.
The objective of this study was to develop functional dark chocolate with improved organoleptic, textural and functional attributes by optimizing the ingredients levels such as flaxseed oil and honey and its further validation for quality improvement. Methods: The chocolate composition was optimized by selecting two variables including flaxseed oil (1-2.5g) and honey (10-15g) at 3 levels in central composite rotatable design (CCRD) by using Design- Expert version 11 software tool. Results: After optimization, the best-predicted formulation comprising flaxseed oil 2.37% (w/w) and honey 15% (w/w) showed best sensorial score (p
Conclusion: The current study clearly demonstrates that the Momordica charantia aryl and seed extracts have the potential to exert its cytotoxic effect on breast cancer cells by a mechanism involving inhibition of EGFR and EGRF related pathways with the induction of apoptosis. The overall finding demonstrates that this plant, especially seed extract, could be a potential source of new anticancer compounds for possible drug development against cancer.