GSE68128 Chronic subacute (incl. one subchronic study) exposure of Wistar rats to (non-)carcinogenic compound

Contributors : Michael R ömer ; Heidrun Ellinger-ZiegelbauerSeries Type : Expression profiling by arrayOrganism : Rattus norvegicusThe carcinogenic potential of chemicals is currently evaluated with rodent life-time bioassays, which are time consuming, and expensive with respect to cost, number of animals and amount of compound required. For insight into early mechanisms of non-genotoxoc carcinogenesis and for identification of potential early biomarkers of non-genotoxic carcinogenesis, groups of rats were treated with a range of known non-genotoxic carcinogens for a period of 14, 28, or 90 days, and liver tissue was harvested for expression profiling. Control groups were treated with appropriate vehicles.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Rattus norvegicus Source Type: research