GSE92437 Expression data from progesterone receptor knockout versus heterozygous mouse ovaries: granulosa cells

Contributors : Lisa K Akison ; Darryl L Russell ; Rebecca L RobkerSeries Type : Expression profiling by arrayOrganism : Mus musculusOvulation requires sequential molecular events and structural remodeling in the ovarian follicle for the successful release of a mature oocyte capable of being fertilised. Critical to this process is progesterone receptor (PGR), a transcription factor highly yet transiently expressed in granulosa cells of preovulatory follicles. Progesterone receptor knockout (PRKO) mice are anovulatory, with a specific and complete defect in follicle rupture. Therefore, this model was used to examine the critical molecular and biochemical mechanisms necessary for successful ovulation.We used microarrays to identify putative PGR-regulated genes in granulosa cells at a time when PGR expression is maximal (eCG + 8h hCG) and the preovulatory follicle is undergoing the final changes necessary for successful ovulation.

Source: GEO: Gene Expression Omnibus - April 20, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research